Recombinant Rat Proprotein convertase subtilisin/kexin type 4 (Pcsk4)

中文名稱：

大鼠Pcsk4重組蛋白
貨號：

CSB-YP017643RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Pcsk4重組蛋白
貨號：

CSB-EP017643RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Pcsk4重組蛋白
貨號：

CSB-EP017643RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pcsk4重組蛋白
貨號：

CSB-BP017643RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pcsk4重組蛋白
貨號：

CSB-MP017643RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pcsk4
Uniprot No.：

Q78EH2
別名：

Pcsk4; Nec-3; Nec3; Proprotein convertase subtilisin/kexin type 4; PC4; EC 3.4.21.-; KEX2-like endoprotease 3; Neuroendocrine convertase 3; NEC 3; Prohormone convertase 3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

111-678
氨基酸序列

SLVVPTDPWF SKQWYMNKEI EQDLNILKVW NQGLTGRGVV VSILDDGIEK DHPDLWANYD PLASYDFNDY DPDPQPRYTP NDENRHGTRC AGEVSATANN GFCGAGVAFN ARIGGVRMLD GAITDIVEAQ SLSLQPQHIH IYSASWGPED DGRTVDGPGL LTQEAFRRGV TKGRQGLGTL FIWASGNGGL HYDNCNCDGY TNSIHTLSVG STTRQGRVPW YSEACASTFT TTFSSGVVTD PQIVTTDLHH QCTDKHTGTS ASAPLAAGMI ALALEANPLL TWRDLQHLVV RASRPAQLQA EDWRINGVGR QVSHHYGYGL LDAGLLVDLA RVWLPTKPQK KCTIRVVHTP TPILPRMLVP KNVTVCCDGS RRRLIRSLEH VQVQLSLSYS RRGDLEIFLT SPMGTRSTLV AIRPLDISGQ GYNNWIFMST HYWDEDPQGL WTLGLENKGY YYNTGTLYYC TLLLYGTAED MTARPQTPQE SHCPLSIVAE LCLISSKQWW WLYSHTQQPV TKGQDSCHPP TTPARQLDQR LHCLFPAPHA GSASEPLQGL SPLAAILAIS LGPWCCPC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2. May also participate in folliculogenesis in the ovaries.
基因功能參考文獻：
1. Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells. PMID: 21080038
亞細胞定位：

Cytoplasmic vesicle, secretory vesicle, acrosome membrane.
蛋白家族：

Peptidase S8 family, Furin subfamily
組織特異性：

Expressed abundantly in the testis. High levels seen in germ cells but not in Leydig, Sertoli or peritubular cells. Expressed in the pachytene spermatocytes and the round spermatids but not in the elongating spermatids. May be expressed within hormonally
數據庫鏈接：

KEGG: rno:171085

STRING: 10116.ENSRNOP00000022358

UniGene: Rn.2899