Recombinant Rat PDZ and LIM domain protein 5 (Pdlim5)

中文名稱：

大鼠Pdlim5重組蛋白
貨號：

CSB-YP726819RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Pdlim5重組蛋白
貨號：

CSB-EP726819RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Pdlim5重組蛋白
貨號：

CSB-EP726819RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pdlim5重組蛋白
貨號：

CSB-BP726819RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pdlim5重組蛋白
貨號：

CSB-MP726819RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pdlim5
Uniprot No.：

Q62920
別名：

Pdlim5; Enh; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-591
氨基酸序列

SNYNVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAS QAHVRIGDVV LSIDGISAQG MTHLEAQNKI KACTGSLNMT LQRASAAAKS EPVAVQKGEP KEVVKPVPIT SPAVSKVTST TNMAYNKVPR PFGSVSSPKV TSIPSPSSAF TPAHAATSSH ASPPPVAAVT PPPLSASGLH ASANPSAAQC SSPPNTGKPA VHVPRQPTVT SVCSESAQEL AEGQRRGSQG DIKQQNGPPR KHIVERNTEF YHIPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEN DNAKKANSTP EPSQQSASPL SAAESLESPG SNRPVVAGLR SAAAFKPVGS TSVKSPSWQR PNQAAPSTGR ISNSASSSGT GAPMKPAVGP PQPSDQDTLV QRAEHIPAGK RTPMCAHCNQ AIRGPFLVAL GKSWHPEEFN CAHCKNTMAY IGFVEEKGAL YCELCYEKFF APECGRCQRK ILGEVINALK QTWHVSCFVC VACGKPIRNN VFHLEDGEPY CETDYYALFG TICRGCEFPI EAGDMFLEAL GSTWHDTCFV CSVCCESLEG QTFFSKKDKP LCKKHAHSVN F
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation.
基因功能參考文獻：
1. results suggest that, in healthy conditions, RBM20 and RBM24 cooperate to promote the expression of short ENH isoforms. PMID: 27289039
2. ENH1 plays an essential role in CREB's activation and dependent transcription in cardiomyocytes. PMID: 26365342
3. PDLIM5 acts as a scaffold protein by mediated PKCepsilon translocated to the membrane in PMA-induced growth cone collapse. PMID: 25524223
4. coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated muscles. PMID: 22497889
5. Neuroligin function was critically dependent on the cytoplasmic tail, but required non-PDZ ligand. PMID: 21532576
6. Antagonistic splice variants of enigma may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy. PMID: 20097676
7. ENH protein, by interacting specifically with both protein kinase C (PKC)epsilon and the N-type Ca2+ channel, targets a specific PKC to its substrate to form a functional signaling complex. PMID: 12665800
8. ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
9. Propose a model where ENH1 scaffolds PKD1 to Cacna1c in order to form a signalling complex that regulates the activity of cardiac L-type voltage-gated Ca(2+) channels. PMID: 18296710
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亞細胞定位：

[Isoform 1]: Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.; [Isoform 2]: Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.
組織特異性：

Detected in brain, in neurons, including in hippocampal neurons, and glial cells (at protein level). Detected in heart and skeletal muscle.
數據庫鏈接：

KEGG: rno:64353

STRING: 10116.ENSRNOP00000022387

UniGene: Rn.17933