Recombinant Rat Ornithine decarboxylase (Odc1)

中文名稱：

大鼠Odc1重組蛋白
貨號：

CSB-YP016269RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Odc1重組蛋白
貨號：

CSB-EP016269RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Odc1重組蛋白
貨號：

CSB-EP016269RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Odc1重組蛋白
貨號：

CSB-BP016269RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Odc1重組蛋白
貨號：

CSB-MP016269RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Odc1
Uniprot No.：

P09057
別名：

Odc1; Odc; Ornithine decarboxylase; ODC; EC 4.1.1.17
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區(qū)域：

1-461
氨基酸序列

MGSFTKEEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDVLK KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG LGVPPERIIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS GCTDPETFVQ AVSDARCVFD MGTEVGFSMY LLDIGGGFPG SEDTKLKFEE ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ TGSDDEDESN EQTLMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY YSSSIWGPTC DGLDRIVERC SLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPNIYYVMS RSMWQLMKQI QSHGFPPEVE EQDVGTLPMS CAQESGMDRH PAACASASIN V
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
基因功能參考文獻：
1. The results indicated that overexpression of ODC gene promotes the proliferation while suppressing apoptosis of fibroblast-like synoviocytes in rats with rheumatoid arthritis. PMID: 28986097
2. These results suggest that IPC upregulates the Ornithine decarboxylase/polyamine system and mediates preconditioning cardioprotection. PMID: 24464033
3. The modulation of ODC activity by AMPK represents a mechanism that may contribute to control cell growth processes. PMID: 22230191
4. effect of deep hypothermia on the ODC activity PMID: 20848911
5. Overexpression of ornithine decarboxylase increases myogenic potential of rat myoblasts. PMID: 20013009
6. The induction of polyamine transport in hypoxic pulmonary artery endothelial cells thus seems to require decreased ODC activity as an initiating event. PMID: 11880311
7. Impaired ODC activity and polyamine production in the kidney may exaggerate salt-sensitive hypertension in Dahl salt sensitive rats. PMID: 12452334
8. temporal profile of renal ODC protein expression and localization, intrarenal polyamine levels, and sites of proliferation in kidneys of rats during the first 7 days of streptozotocin diabetes PMID: 12716758
9. Spermidine induces precocious maturation of glucose transporters in the small intestine, which may be mediated by alterations in ODC expression. PMID: 17673438
10. Corticosterone decreases ODC mRNA and enzyme protein both in the intact liver and the regenerating liver. PMID: 17914980
11. The aim of this study was to investigate the role of TG2, ODC, and their products in regenerating rat liver after partial hepatectomy by using retinoic acid. PMID: 18008394
12. ODC is necessary for hyperresponsiveness of the proximal tubule to dietary salt and for the paradoxical effect of dietary salt on GFR in early diabetes PMID: 18562630
13. Results show that transglutaminase-catalyzed polyamination of rhoA regulates its activity, and that ornithine decarboxylase influences the intracellular distribution of rhoA. PMID: 19331812
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蛋白家族：

Orn/Lys/Arg decarboxylase class-II family
數(shù)據(jù)庫鏈接：

KEGG: rno:24609

STRING: 10116.ENSRNOP00000007259

UniGene: Rn.874