Recombinant Rat Myocyte-specific enhancer factor 2A (Mef2a)

中文名稱：

大鼠Mef2a重組蛋白
貨號：

CSB-YP641752RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Mef2a重組蛋白
貨號：

CSB-EP641752RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Mef2a重組蛋白
貨號：

CSB-EP641752RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Mef2a重組蛋白
貨號：

CSB-BP641752RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Mef2a重組蛋白
貨號：

CSB-MP641752RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mef2a
Uniprot No.：

Q2MJT0
別名：

Mef2a; Myocyte-specific enhancer factor 2A
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-495
氨基酸序列

MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLAESSML SPPPATLHRN VSPGAPQRPP STGSAGGMLS TTDLTVPNGA GNGPVGNGFV DSRASPNLIG NTGANSVGKV MPTKSPPPPG GGSVGMNSRK PDLRVVIPPS SKGMMPPLNA QRISSSQATQ PLATPVVSVT TPSLPPQGLV YSAMPTAYNT DYSLTSADLS ALQGFTSPGM LSLGQASAWQ QHHLGQAALS SLVAGGQLSQ GSNLSINTNQ NINIKTEPIS PPRDRMTPSG FQQQQQQQPQ QQPPPQPPQP QPQPRQEMGR SPVDSLSSSS SSYDGSDRED PRGDFHSPIV LGRPPNAEDR ESPSVKRMRM DTWVT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
基因功能參考文獻：
1. MEF2A participates in neuronal differentiation/maturation from neural stem cells. PMID: 29678571
2. Animal physical conditioning increases hyper-acetylation of histones and increased the expression of NRF-1 and MEF2A genes. PMID: 28263745
3. microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A PMID: 26240138
4. The results of this study discovered a MEF2A-dependent transcriptional mechanism that plays an essential role in the regulation of presynaptic differentiation in the rat brain. PMID: 23486945
5. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity. PMID: 22622902
6. The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle. PMID: 21724844
7. Muscle contraction leads to a rapid increase of MEF2A mRNA. PMID: 16024167
8. findings report a requirement for MEF2A in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex PMID: 16484498
9. PIASx is a MEF2A E3 ligase that promotes the differentiation of postsynaptic granule neuron dendrites in the cerebellar cortex. PMID: 17855618
10. This study demonstrates for the first time extensive cytoplasmic localization of a MEF2 transcription factor in the mammalian brain in vivo PMID: 19362076
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: rno:309957

STRING: 10116.ENSRNOP00000065122

UniGene: Rn.162435