Recombinant Rat Metabotropic glutamate receptor 7 (Grm7), partial

中文名稱：

大鼠Grm7重組蛋白
貨號：

CSB-YP009937RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Grm7重組蛋白
貨號：

CSB-EP009937RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Grm7重組蛋白
貨號：

CSB-EP009937RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Grm7重組蛋白
貨號：

CSB-BP009937RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Grm7重組蛋白
貨號：

CSB-MP009937RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grm7
Uniprot No.：

P35400
別名：

Grm7; Gprc1g; Mglur7Metabotropic glutamate receptor 7; mGluR7
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
基因功能參考文獻(xiàn)：
1. Findings demonstrated that the glutamic acid and mGluR7 in hippocampal CA3 region are involved in the modulation of nociceptive information transmission by regulating pain-evoked electric activities of pain-excited neurons and pain-inhibited neurons. PMID: 27488423
2. Study indicates that functional activation of accumbal mGluR7 has antinociceptive effects that interfere with relief learning PMID: 27296637
3. Study demonstrated that mGluR7 can signal constitutively (in the absence of agonist) when expressed in neurons PMID: 25881041
4. Activation of mGluR7 can produce antiparkinsonian-like effects in rats. PMID: 24399715
5. These results show that levels of mGluR7 in the Nucleus Accumbens regulate responsiveness to alcohol. PMID: 22781839
6. Agonist-induced dephosphorylation of mGluR7 is regulated by PP1. PMID: 23612982
7. mGluR7 was expressed in the rat peptidergic dorsal root ganglion (DRG) neurons and large neurons, but rarely in isolectin B4 positive neurons. PMID: 23085525
8. analysis of extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats PMID: 22479593
9. mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function PMID: 22287544
10. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals PMID: 11825890
11. The specific location of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic synapses on interneurons in the somatosensory cortex is related to the proximity of calcium channels and the vesicle fusion machinery. PMID: 12183395
12. mGluR7 selectively reduced the release component that is associated with N-type Ca2+ channels PMID: 12692128
13. Glutamate by means of activation of mGluRs may have broad sphere of physiological influence in brain. Modulates synaptic transmission. May also have role in determining microvascular function and dysfunction. PMID: 12746871
14. group III mGluRs regulate in vivo extracellular glutamate in the nucleus accumbens by inhibiting non-vesicular glutamate release PMID: 14622100
15. AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats. PMID: 19154087
16. The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. PMID: 19374778
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 3 family
組織特異性：

Widely distributed throughout the brain.
數(shù)據(jù)庫鏈接：

KEGG: rno:81672

STRING: 10116.ENSRNOP00000053411

UniGene: Rn.10409