Recombinant Rat Hepcidin (Hamp), partial

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中文名稱：

大鼠Hamp重組蛋白
品名簡稱：

Recombinant Rat Hamp protein, partial
貨號：

CSB-YP860393RA
說明書：

MSDS Datasheet
規格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Hamp
Uniprot No.：

Q99MH3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
來源：

Yeast
分子量：

4.2 kDa
表達區域：

60-84aa
氨基酸序列

DTNFPICLFCCKCCKNSSCGLCCIT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.; Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
基因功能參考文獻：
1. Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-kappaB Activation. PMID: 29147463
2. In experimental autoimmune encephalomyelitis, we recently found that chronic iron overload influences the course of disease. In females, iron overload accelerated the onset of disease, while in males it accelerated the progression of disease and increased mortality rate. We hypothesize that those differences arise on molecular level in different expression of stress response proteins hepcidin and metallothioneins. PMID: 28915963
3. Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels PMID: 26944476
4. when a high erythropoietic stimulus occurs, hepcidin synthesis is mainly regulated by transferrin saturation; however, when the erythropoiesis rate reaches a specific threshold, extramedullary hematopoiesis is triggered, and the control of hepcidin synthesis is switched to matriptase-2, thus inhibiting hepcidin synthesis. PMID: 27282570
5. The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of breast cancer cells malignant phenotype and their resistance to doxorubicin. PMID: 27356575
6. downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of subarachnoid hemorrhage . PMID: 27250827
7. liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia PMID: 26990350
8. Rats were treated with different dose levels of a monoclonal antibody that downregulates Hepcidin; results of this morphometric analysis in the liver showed that iron accumulation is not homogenous between liver lobes and the left lateral lobe was the most responsive lobe in the rat. PMID: 26839325
9. Hepcidin may be considered as a potential marker of impaired renal function. PMID: 26907911
10. a significant decrease of hepcidin expression is observed during late-pregnancy and early-lactation stages, suggesting the important regulatory role that hepcidin plays in iron metabolism during pregnancy and lactation PMID: 26788496
11. Study investigated the expression of hepcidin mRNA and protein in normal rat brain and to interpret the findings in the light of the properties of hepcidin as a peptide hormone with an essential role in systemic iron homeostasis PMID: 25896789
12. liver congestion induces hepcidin production, which may result in anemia and functional iron deficiency in some patients with heart failure. PMID: 25742771
13. Vitamin A deficiency reduced serum iron and transferrin saturation levels, increased spleen iron concentrations, reduced hepatic Hamp and kidney erythropoietin messenger RNA levels and up-regulated hepatic and spleen heme oxygenase-1 gene expression. PMID: 24998947
14. Data indicate that a moderate decrease in hepatic hepcidin mRNA content was observed in male rats. PMID: 24962641
15. inhibition of hepcidin may reduce many pathological changes seen in stress-induced depressive disorders. PMID: 25576700
16. This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis PMID: 25580431
17. Colitis increased local hepcidin-25 expression, which was associated with the IL-6/Stat-3 signaling pathway PMID: 24764672
18. High hepcidin serum expression levels correlated with an impaired hematologic response to an erythropoiesis-stimulating agent in rats with anemia of chronic disease. PMID: 24895335
19. Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats. PMID: 24424338
20. Data indicate that Hepcidin expression is increased in response to serum treatment in liver cells. PMID: 25151311
21. Data suggest that hepcidin was a relevant indicator for renal I/R injury diagnosis. PMID: 23439664
22. hepcidin inhibits expression of iron release as well as iron uptake proteins in macrophages PMID: 22560353
23. Angelica sinensis polysaccharide significantly reduced hepcidin expression by inhibiting the expression of (SMAD4) in liver and stimulating the secretion of erythropoietin. PMID: 22985399
24. result strongly suggests that plasma Il-6 is involved in exercise-induced increase of hepcidin gene expression PMID: 22326661
25. We found that hepcidin mRNA levels were significantly reduced in the regenerating liver after the acute-phase response was completed. PMID: 22364558
26. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia PMID: 21859731
27. Hepcidin controls iron uptake and release by regulating expression of iron transport proteins, implying the existence of a novel hepcidin-receptor on the membrane of astrocytes. PMID: 21438013
28. hepcidin is an important contributor to iron overload in cerebral ischemia PMID: 21957487
29. Downregulation of hepcidin (Hamp) gene, a key regulator of Fpn1 was accompanied by decreased levels of CCAAT/enhancer binding proteins alpha and beta, especially at the Hamp promoter. PMID: 21785164
30. Although liver Fe concentration was significantly higher in rats fed an Mg-deficient diet for 4 weeks than in rats fed a control diet, Hepcidin expression in the liver was comparable between the dietary groups. PMID: 21736832
31. hepcidin inhibits the expression of iron-absorption proteins and led to exercise-associated anemia. PMID: 21411831
32. Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression PMID: 20937842
33. investigation of up-regulation of hepcidin in myocardium following myocardial infarction; comparison of ischemic tissue vs. remote myocardial tissue PMID: 20553779
34. With the increases of iron levels in diet, the levels of serum iron, serum ferretin, and transferrin saturation were gradually increased, and the hepcidin mRNA expression level in liver significantly increased. PMID: 18839536
35. regulation of hepatic transcription by C/EBPalpha PMID: 12183449
36. hepcidin mediates lipopolysaccharide-induced downregulation of intestinal ferroportin 1 expression and the hepcidin signaling pathway involves a pyrrolidinedithiocarbamate-sensitive step PMID: 14592944
37. In liver ischemia-reperfusion model of acute inflammation, mechanism(s) other than interleukin-6 signal transduction via signal transducers and activators of transcription-3 may be responsible for hepcidin induction. PMID: 15973703
38. HAMP expression differs in cultured as compared with freshly isolated hepatocytes, and decreases in iron-loaded hepatocytes in serum free-media, suggesting that additional serum factors influence HAMP expression. PMID: 16221503
39. Hepcidin may have an important role in cardiac diseases. PMID: 17363462
40. hepcidin may play a major, causative role in the change of FPN1 synthesis PMID: 18189270
41. Lipopolysaccharides induced a significant increase in the expression of hepcidin mRNA and protein in the cortex and substantia nigra. PMID: 18450970
42. IL-6-hepcidin axis is up-regulated by psychological stress in rats. PMID: 18541141
43. overproduction of HIF-1alpha and the activation of caspase-3 seem to be associated with iron deficiency and with inflammatory markers. Hepcidin seems to plays a key role in this mechanism. PMID: 18808386
44. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling. PMID: 19008338
45. Phagocytosis upregulates hepcidin-gene expression and downregulates Hjv- and Fpn-1-gene expression within the liver. PMID: 19721414
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亞細胞定位：

Secreted.
蛋白家族：

Hepcidin family
數據庫鏈接：

KEGG: rno:84604

STRING: 10116.ENSRNOP00000028545

UniGene: Rn.7865