Recombinant Rat Glia-derived nexin (Serpine2)

中文名稱：

大鼠Serpine2重組蛋白
貨號：

CSB-YP021082RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Serpine2重組蛋白
貨號：

CSB-EP021082RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Serpine2重組蛋白
貨號：

CSB-EP021082RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Serpine2重組蛋白
貨號：

CSB-BP021082RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Serpine2重組蛋白
貨號：

CSB-MP021082RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Serpine2
Uniprot No.：

P07092
別名：

Serpine2; Pi7; Pn1Glia-derived nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-397
氨基酸序列

S QLNSLSLEEL GSDTGIQVFN QIIKSQPHEN VVISPHGIAS ILGMLQLGAD GRTKKQLSTV MRYNVNGVGK VLKKINKAIV SKKNKDIVTV ANAVFVRNGF KVEVPFAARN KEVFQCEVQS VNFQDPASAC DAINFWVKNE TRGMIDNLLS PNLIDSALTK LVLVNAVYFK GLWKSRFQPE NTKKRTFVAG DGKSYQVPML AQLSVFRSGS TKTPNGLWYN FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTINSW MNTMVPKRMQ LVLPKFTALA QTDLKEPLKA LGITEMFEPS KANFAKITRS ESLHVSHILQ KAKIEVSEDG TKAAVVTTAI LIARSSPPWF IVDRPFLFCI RHNPTGAILF LGQVNKP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
基因功能參考文獻：
1. data indicate that serpinE2 is up-regulated by oncogenic activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic actions of ERK signaling in intestinal epithelial cells. PMID: 20942929
2. Expression of protease nexin-1 does not change significantly in the hippocampus following severe ischemic insult. PMID: 12165407
3. Protease nexin-1 (PN-1) modulates the activity of endogenous and exogenous serine proteases in vascular smooth muscle; thrombin down-regulates PN-1 expression and thus may increase its own activity on cells. PMID: 15281096
4. Up-regulation of PN-1 expression stabilizes and protects Dense-core secretory granule proteins against degradation. PMID: 16319172
亞細胞定位：

Secreted, extracellular space.
蛋白家族：

Serpin family
數據庫鏈接：

KEGG: rno:29366

STRING: 10116.ENSRNOP00000020919

UniGene: Rn.2271