Recombinant Rat Furin (Furin), partial

中文名稱(chēng)：

大鼠Furin重組蛋白
貨號(hào)：

CSB-YP009068RA1
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

大鼠Furin重組蛋白
貨號(hào)：

CSB-EP009068RA1
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

大鼠Furin重組蛋白
貨號(hào)：

CSB-EP009068RA1-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

大鼠Furin重組蛋白
貨號(hào)：

CSB-BP009068RA1
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

大鼠Furin重組蛋白
貨號(hào)：

CSB-MP009068RA1
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Furin
Uniprot No.：

P23377
別名：

Furin; Fur; Pcsk3; Furin; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; Prohormone convertase 3
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45).
基因功能參考文獻(xiàn)：
1. these data suggest that furin may play an important role in regulating apoptosis and proliferation of granulosa cells. PMID: 23418414
2. upregulated during the preovulatory period, which results in activation of proteinases associated with the breakdown of the follicular wall during ovulation PMID: 20375258
3. integrin bidirectional signalling is critically controlled by furin PMID: 20076849
4. significant pools of furin and proMT1-MMP along the surface of cells lining glomerular basement membranes PMID: 12665557
5. CDX2 regulates furin expression in intestinal epithelial cells PMID: 16239403
6. Disturbances of the MT1-MMP/furin interaction must account for a lack in extracellular matrix remodeling, increased deposition of glomerular basement membrane material, and loss of glomerular filtration integrity in diabetic glomerulopathy. PMID: 16541018
顯示更多

收起更多
亞細(xì)胞定位：

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein.
蛋白家族：

Peptidase S8 family, Furin subfamily
組織特異性：

Cardiocytes (at protein level).
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:54281

STRING: 10116.ENSRNOP00000015521

UniGene: Rn.3220