Recombinant Rat Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl)

中文名稱：

大鼠Dnph1重組蛋白
貨號：

CSB-YP518579RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Dnph1重組蛋白
貨號：

CSB-EP518579RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Dnph1重組蛋白
貨號：

CSB-EP518579RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Dnph1重組蛋白
貨號：

CSB-BP518579RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Dnph1重組蛋白
貨號：

CSB-MP518579RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dnph1
Uniprot No.：

O35820
別名：

Dnph1; Rcl2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC 3.2.2.-; Deoxyribonucleoside 5'-monophosphate N-glycosidase; c-Myc-responsive protein Rcl
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-163
氨基酸序列

AASGEQAPC SVYFCGSIRG GREDQALYAR IVSRLRRYGK VLTEHVADAE LEPLGEEAAG GDQFIHEQDL NWLQQADVVV AEVTQPSLGV GYELGRAVAL GKPILCLFRP QSGRVLSAMI RGAADGSRFQ VWDYAEGEVE TMLDRYFEAY LPQKTASSSH PSA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
基因功能參考文獻：
1. The crystal structure of oncoprotein Rcl bound to thymidine analogue 6-RADP-1-C6PA confirms and more precisely reveals the organization of its nucleotide-binding site. PMID: 23385460
2. analysis of human deoxynucleotide N-hydrolase Rcl and rat gene c6orf108 PMID: 20962348
3. rcl as an important antiapoptotic protein mediating sensitivity to Coptidis Rhizoma induction in cancer cells PMID: 11991256
4. C6orf108 encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase PMID: 17234634
5. RCL is a symmetric homodimer, with each monomer consisting of a five-stranded parallel beta-sheet sandwiched between five alpha-helices. Three of the helices form the dimer interface, allowing two monomers to pack side by side. PMID: 19720067
6. ligand-induced stabilization of the dimer structure of the enzyme PMID: 19822152
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
組織特異性：

Highly expressed in heart, kidney, liver and spleen. Weakly expressed in lung and skeletal muscle.
數據庫鏈接：

KEGG: rno:171047

STRING: 10116.ENSRNOP00000024815

UniGene: Rn.6997