Recombinant Rat Aggrecan core protein (Acan), partial

中文名稱：

Recombinant Rat Aggrecan core protein (Acan), partial
品名簡稱：

Recombinant Rat Acan protein, partial
貨號：

CSB-EP001130RA
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Acan
Uniprot No.：

P07897
別名：

Cartilage-specific proteoglycan core protein;CSPCP
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
來源：

E.coli
分子量：

19.5 kDa
表達區域：

34-147aa
氨基酸序列

PQPSPLKALLGTSLTIPCYFIDPMHPVTTAPSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
基因功能參考文獻：
1. To elucidate the transcriptional mechanism that leads to abundant expression of aggrecan by chondrocytes, it screened for enhancer elements in 130 kb of the aggrecan gene, Agc1, using a reporter assay system that we previously developed. PMID: 24554731
2. Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Agc1 gene expression. PMID: 24647564
3. Data suggest that expression of aggrecan and matrix metallopeptidase 13 in femur of female neonatal rats is altered by maternal vitamin A status and neonatal diet (i.e., supplementation with vitamin A and retinoic acid). PMID: 22357747
4. We suggest that the role of aggrecan is to maintain retinal ganglion cell dendritic structure in the inner plexiform layer and to provide adequate support and flexibility for the photoreceptor outer segments, which is necessary to maintain their function. PMID: 22306080
5. Data show that an increase in collagen-II, aggrecan, and Sox-9 protein expression in NP and AF regions of the disc was detected in the exercised rats. PMID: 20592578
6. Using in vitro assays of cell migration, we show that aggrecan produced by astrocytes is involved in the inhibition of Schwann cell motility on astrocytic monolayers. PMID: 20155822
7. A remote upstream element regulates tissue-specific expression of the rat aggrecan gene PMID: 11834732
8. cleaved by ADAMTS1 and diffrenteially inhibited by metalloproteinase inhibitors PMID: 12054629
9. Data suggest that versican and aggrecan have partially complementary roles during central nervous system development. PMID: 12701107
10. PI3K/AKT signaling controls aggrecan gene expression, in part by modulating Sox9 expression and activity in cells of the nucleus pulposus. PMID: 19711351
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Aggrecan/versican proteoglycan family
數據庫鏈接：

KEGG: rno:58968

STRING: 10116.ENSRNOP00000042691

UniGene: Rn.54503