Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A (Anp32a)

中文名稱：

Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a)
貨號：

CSB-YP001822RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a)
貨號：

CSB-EP001822RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a)
貨號：

CSB-EP001822RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a)
貨號：

CSB-BP001822RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a)
貨號：

CSB-MP001822RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Anp32a
Uniprot No.：

P49911
別名：

Anp32a; LanpAcidic leucine-rich nuclear phosphoprotein 32 family member A; Leucine-rich acidic nuclear protein; LANP
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-247
氨基酸序列

MEMDKRIYLE LRNRTPSDVK ELVLDNCRSI EGKIEGLTDE FEELEFLSTI NVGLTSISNL PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI KDLSTIEPLK KLENLKSLDL FNCEVTNLNA YRENVFKLLP QVMYLDGYDR DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY AQLVEDEEEE DEEEEGEEED VSGEEEEDEE GYNDGEVDDE EDEEDAAEEE GSQKRKREPD DEGQEDD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.
基因功能參考文獻：
1. these findings suggest that Lanp can interact with Rb in both young and mature neurons and is implicated in the regulation of neuronal survival by CXCL12/CXCR4 PMID: 20617464
2. LANP interacts directly with the cytosolic domains of rat brain neural cell adhesion molecule (NCAM) 140 and 180 isoforms. PMID: 15865439
3. LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels PMID: 19136565
亞細胞定位：

Nucleus. Cytoplasm. Endoplasmic reticulum.
蛋白家族：

ANP32 family
組織特異性：

Widely distributed in the central nervous system, with an abundant expression in the cerebellum.
數據庫鏈接：

KEGG: rno:25379

STRING: 10116.ENSRNOP00000066098

UniGene: Rn.10123