Recombinant Pig Leptin receptor (LEPR), partial

中文名稱：

野豬LEPR重組蛋白
貨號：

CSB-YP012871PI
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

野豬LEPR重組蛋白
貨號：

CSB-EP012871PI
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

野豬LEPR重組蛋白
貨號：

CSB-EP012871PI-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

野豬LEPR重組蛋白
貨號：

CSB-BP012871PI
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

野豬LEPR重組蛋白
貨號：

CSB-MP012871PI
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LEPR
Uniprot No.：

O02671
別名：

LEPR; OBRLeptin receptor; LEP-R; OB receptor; OB-R; CD antigen CD295
種屬：

Sus scrofa (Pig)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for hormone LEP/leptin. On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production.
基因功能參考文獻：
1. polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs PMID: 28872194
2. study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function PMID: 23824082
3. LEPR showed a lower variability than LEP in the different analysed populations, especially in the Iberian breed that showed no variability PMID: 25910874
4. Superactive human leptin antagonist reverses leptin-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin receptors. PMID: 25716963
5. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries. PMID: 25363738
6. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs. PMID: 24128088
7. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process. PMID: 25245493
8. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin PMID: 24407604
9. Leptin and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy. PMID: 24101399
10. These data suggest that leptin might have a direct effect on porcine follicles and plays an important role in the follicular development. PMID: 23691582
11. Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs. PMID: 23031202
12. results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake PMID: 22497241
13. These results of the current study indicated that the c.2002C>T SNP of LEPR has a strong effect on BF, fat area ratios and LEPC. PMID: 22574789
14. The differences in luteal function in leptin resistance genotype and lean genotype swine due to leptin receptor polymorphism are reported. PMID: 21385231
15. Conceptus viability and growth were found to be related to the placental expression of the vascular endothelial growth factor A (VEGFA) and leptin (LEP) genes. PMID: 22251656
16. A polymorphism in LEPR decreased the yield of premium cuts of meat. PMID: 21196086
17. 87C>T polymorphism is associated with body weight and back fat thickness PMID: 21128076
18. The objective of this study was to investigate the effect of FABP3 and LEPR genetic variations as well as their mRNA expression on the intramuscular fat content trait in a three-generation of Korean native pig and Yorkshire crossed animals. PMID: 20300864
19. These results indicate that both leptin and OB-Rb are synthesized in the porcine hypothalamus and participate in control of reproduction during the oestrous cycle and early pregnancy. PMID: 19000220
20. Data show that treatment with GH or IGF-I reduced leptin receptor expression, and increased Phosphorylation of ERK1/2 in response to acute leptin. PMID: 19786114
21. long form leptin receptor was expressed in the hypothalamus, pituitary and adipose tissue in the pig during early pregnancy (at days 14-16 and 30-32) PMID: 16136021
22. an important role of IGF-I in leptin receptor expression during the entire estrous cycle, with a special role during the prepubertal period PMID: 17139134
23. The OB-Rb gene expression in ovarian structures was higher during early pregnancy in comparison to the mid- and late-luteal phase of the estrous cycle. PMID: 17435831
24. Changes in OB-Rb gene and protein expression in tissues of pig reproductive tract strongly suggest that their sensitivity to leptin varies throughout luteal phase of the cycle and early pregnancy. PMID: 18619745
25. Intrauterine growth retardation (IUGR) may be characterized by altered leptin receptor distribution within the hypothalamic structures involved in metabolic regulation Leptin supplementation can partially reverse the IUGR phenotype. PMID: 18780769
26. results supported the association between LEPR alleles and backfat thickness in the Iberian x Landrace cross, and within the Iberian x Meishan cross and another association between LEPR alleles and body weight was identified in both populations PMID: 18952727
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.
蛋白家族：

Type I cytokine receptor family, Type 2 subfamily
組織特異性：

Kidney, liver, spleen, lung, brain, testis, uterus, ovary, corpus luteum, theca and granulosa cells.
數據庫鏈接：

KEGG: ssc:396836

STRING: 9823.ENSSSCP00000022838

UniGene: Ssc.263