Recombinant Pig Heat shock protein beta-1 (HSPB1)

中文名稱：

野豬HSPB1重組蛋白
貨號：

CSB-YP732844PI
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

野豬HSPB1重組蛋白
貨號：

CSB-EP732844PI
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

野豬HSPB1重組蛋白
貨號：

CSB-EP732844PI-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

野豬HSPB1重組蛋白
貨號：

CSB-BP732844PI
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

野豬HSPB1重組蛋白
貨號：

CSB-MP732844PI
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HSPB1
Uniprot No.：

Q5S1U1
別名：

HSPB1; HSP27; Heat shock protein beta-1; HspB1; Heat shock 27 kDa protein; HSP 27
種屬：

Sus scrofa (Pig)
蛋白長度：

full length protein
表達區域：

1-207
氨基酸序列

MTERRVPFSL LRSPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS GWPGYVRPLP PPAIEGPAAV AAPAYSRLLS RQLSSGVSEI QQTADRWRVS LDVNHFAPEE LTVKTKDGVV EITGKHEERQ DEHGFISRCF TRKYTLPPGV DPTQVSSSLS PEGTLSVEAP LPKPATQSAE ITIPVTFEAR AQLGGTEAGK SEKPGTK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
基因功能參考文獻：
1. Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway. PMID: 29525670
2. It indicated that Hsp27 was required for porcine circovirus type 2 replication in PK-15 cells culture. PMID: 24907481
3. HSP27 expression is gut region- and cell type-specific in response to dietary components, microbes, and microbial metabolites to which the mucosa surface is exposed. PMID: 24763551
4. These results indicate that Hsp27 expression in the porcine gut could be associated with specific dietary fiber components but not the overall microbiota diversity. PMID: 23365273
5. Data suggest that targeting HSP27 might offer a useful strategy in cancer treatment. PMID: 22589302
6. Data show that the expression of HSP27 and CLIC1 was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively. PMID: 21858536
7. Data suggest that HSP27 enhanced the metastatic property of NPC cells probably via the NF-kappaB-mediated activation of MMPs. PMID: 21717573
8. Hsp27 expression and its direct chaperoning interaction increase Akt stability and p21 phosphorylation and nuclear-to-cytoplasm translocation, both essential effects for the survival of ultraviolet-induced DNA-damaged cells. PMID: 20858736
9. HSP27 could be a good candidate involved in migration and/or function of neutrophils within the porcine endmetrium. PMID: 20541878
10. HSP27 and HSP70 may be used as differential markers to distinguish conventional and low grade central osteosarcoma. PMID: 20632817
11. HSP-27 and HSP-70 contribute to modulation of K(+) channel-induced pial artery dilation PMID: 15908467
12. HSP27 in the retinas of 1-day-old piglets and showed that it was enhanced in the retinas of 6-month-old adult. And was seen mainly in ganglion cell bodies in the ganglion cell layer, and in some processes of astrocytes in the innermost nerve fiber layer. PMID: 16930837
13. Extremely low frequency magnetic field exposure affected the cellular distribution of Hsp27; in particular a partial relocalization in the nucleus was observed. PMID: 17080460
14. Hsp27 is dephosphorylated by PP2A in dorsal ruffles, in non-caveolar lipid raft microdomains. PMID: 19109948
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.
蛋白家族：

Small heat shock protein (HSP20) family
數據庫鏈接：

KEGG: ssc:493184

STRING: 9823.ENSSSCP00000008216

UniGene: Ssc.5832