Recombinant Mouse Zinc finger protein 521 (Znf521), partial

中文名稱：

小鼠Znf521重組蛋白
貨號：

CSB-YP026811MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Znf521重組蛋白
貨號：

CSB-EP026811MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Znf521重組蛋白
貨號：

CSB-EP026811MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Znf521重組蛋白
貨號：

CSB-BP026811MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Znf521重組蛋白
貨號：

CSB-MP026811MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Znf521
Uniprot No.：

Q6KAS7
別名：

Znf521; Evi3; Zfp521; Zinc finger protein 521; Ecotropic viral integration site 3 protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
基因功能參考文獻：
1. The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway. PMID: 26522721
2. these results identify ZNF521/ZFP521 as a critical regulator of HSC function, which facilitates MLL-AF9-mediated leukemic disease in mice. PMID: 28615219
3. links between dysregulated Zfp521 and B-cell survival PMID: 27107743
4. Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner. PMID: 27506447
5. Data suggest a facilitated approach for establishing human neural stem cells (NSCs) through zinc finger protein 521 (Zfp521)-driven conversion of fibroblasts. PMID: 27052315
6. it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells PMID: 26949089
7. Data show that zinc finger protein 521 (ZNF521) overexpression repressed osteoblastic differentiation of C3H10T1/2 cells. PMID: 26008984
8. Runx1-dependent transcription factor gene Zfp521 is expressed in, and required for establishing molecular features that define, mechanoreceptors. PMID: 25834056
9. the data suggest that Zfp521 is a cell fate switch critical for BMP-induced osteoblast commitment and identify Zfp521 as the intrinsic repressor of Zfp423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation. PMID: 24891617
10. the interplay between Zfp521 and Ebf1 is identified as a novel rheostat for bone homeostasis. PMID: 23569325
11. Reduction of Zfp521 enhances adipogenic potential in vivo. PMID: 23209378
12. Zfp521 is a nuclear protein with 30 Kruppel-like zinc fingers mediating multiple protein-protein interactions, and regulates transcription in diverse tissues and organs. PMID: 21539723
13. we found the expression of Zfp521 declined with the neural differentiation of bone marrow mesenchymal stem cells, and miR-9 could promote the neural differentiation via targeting Zfp521. PMID: 22465325
14. This study provides the first genetic evidence that Zfp521 is required downstream of PTHR1 signaling to act on chondrocyte proliferation, differentiation, and cell death. PMID: 21642473
15. transition of ES cell differentiation from the epiblast state into neuroectodermal progenitors specifically depends on the cell-intrinsic expression and activator function of Zfp521 PMID: 21326203
16. The balance and HDAC3-dependent molecular interplay between Zfp521 and Runx2 contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis. PMID: 21173110
17. Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation. PMID: 20951345
18. Evi3 encodes an EBFAZ-related Kruppel-like zinc finger protein. Evi3 expression could be detected at all stages of B-cell development. EVI3, not EBFAZ, is the member of this protein family that interacts with and regulates early b-cell factor in B cells. PMID: 12393497
19. Evi3 misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with Early B-cell Factor (EBF). PMID: 15580294
20. ZNF521 modulates erythroid cell differentiation through direct binding with GATA-1. PMID: 19049973
21. Zfp521 regulates the rate of osteoblast differentiation and bone formation during development and in the mature skeleton, in part by antagonizing Runx2. PMID: 19095088
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相關疾病：

Defects in Znf521 are a cause of B-cell lymphomas. Znf521 gene is a frequent target of retroviral integration in murine B-cell lymphomas. Involved in most B-cell tumors in the AKXD-27 strain. Viral insertion causes overexpression resulting in the up-regulation of EBF1-target gene expression. Misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with EBF1.
亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
組織特異性：

Widely expressed. Expressed in all B-cell stages.
數據庫鏈接：

KEGG: mmu:225207

STRING: 10090.ENSMUSP00000025288

UniGene: Mm.40325