Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 13 (Ptpn13), partial

中文名稱：

小鼠Ptpn13重組蛋白
貨號：

CSB-YP734108MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ptpn13重組蛋白
貨號：

CSB-EP734108MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ptpn13重組蛋白
貨號：

CSB-EP734108MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ptpn13重組蛋白
貨號：

CSB-BP734108MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ptpn13重組蛋白
貨號：

CSB-MP734108MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ptpn13
Uniprot No.：

Q64512
別名：

Ptpn13; Ptp14; Tyrosine-protein phosphatase non-receptor type 13; EC 3.1.3.48; PTP36; Protein tyrosine phosphatase DPZPTP; Protein tyrosine phosphatase PTP-BL; Protein-tyrosine phosphatase RIP
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
基因功能參考文獻：
1. contributions of Fap1 to tyrosine kinase inhibitors (TKI)resistance, CML blast crisis, and relapse after TKI discontinuation PMID: 26984787
2. The data show that the levels of PTPN13 and beta-catenin must be strictly regulated by extracellular signaling to regulate hematopoietic stem cells attachment to the bone marrow niche and the balance between proliferation and quiescence. PMID: 26344907
3. The study presents a detailed kinetics analysis of the interaction between PTP-BL PDZ2 domain and a peptide mimicking the PDZ binding motif of APC. PMID: 24928580
4. SDCCAG3 forms a complex with PTPN13. Interaction of SDCCAG3 with PTPN13 is mediated via the FERM domain of PTPN13 and via the N-terminus of SDCCAG3. PMID: 23108400
5. Data indicate that Bcr-abl increases PTPN13 promoter activity in an Icsbp-dependent manner. PMID: 22891763
6. Since PTPL1 catalytic activity is important for cell transformation, VCP regulation by PTPL1 might be important for tumorigenesis. PMID: 23018179
7. These findings demonstrate a key role for PTP-BL in 3T3-L1 and mouse embryo fibroblasts-derived adipocyte differentiation that is independent of its enzymatic activity. PMID: 19782949
8. Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL PMID: 11884147
9. With delayed kinetics, ephrinB ligands recruit the cytoplasmic PDZ domain containing protein tyrosine phosphatase PTP-BL and are dephosphorylated. PMID: 11983165
10. FAP-1 has a role in binding to, and consequently inhibition of, Fas export to the cell surface PMID: 12724420
11. examination of potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton PMID: 12839623
12. In alternatively spliced variant structural changes have imp[lications in the functional role of PTP-BL PMID: 14725761
13. a very mild but significant impairment of motor nerve repair was observed in PTP-BL mutant mice PMID: 15226483
14. Involved in the regulation of the meiotic cell cycle. PMID: 15371306
15. PTP-BL facilitates both retinal ganglion cell neurite initiation and survival of activated retinal glia PMID: 15932596
16. Different pools of PTP-BL-containing protein complexes can be discerned in neuronal cells, reflecting distinct molecular microenvironments in which PTP-BL may exert its function. PMID: 16388334
17. The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells PMID: 18195016
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亞細胞定位：

Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class subfamily
組織特異性：

Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis.
數據庫鏈接：

KEGG: mmu:19249

STRING: 10090.ENSMUSP00000048119

UniGene: Mm.3414