Recombinant Mouse Tripartite motif-containing protein 30A (Trim30a)

中文名稱：

小鼠Trim30a重組蛋白
貨號：

CSB-YP325362MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Trim30a重組蛋白
貨號：

CSB-EP325362MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Trim30a重組蛋白
貨號：

CSB-EP325362MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Trim30a重組蛋白
貨號：

CSB-BP325362MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Trim30a重組蛋白
貨號：

CSB-MP325362MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Trim30a
Uniprot No.：

P15533
別名：

Trim30a; Rpt-1; Rpt1; Trim30; Tripartite motif-containing protein 30A; Down regulatory protein of interleukin-2 receptor; Tripartite motif-containing protein 30
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-496
氨基酸序列

MASSVLEMIK EEVTCPICLE LLKEPVSADC NHSFCRACIT LNYESNRNTD GKGNCPVCRV PYPFGNLRPN LHVANIVERL KGFKSIPEEE QKVNICAQHG EKLRLFCRKD MMVICWLCER SQEHRGHQTA LIEEVDQEYK EKLQGALWKL MKKAKICDEW QDDLQLQRVD WENQIQINVE NVQRQFKGLR DLLDSKENEE LQKLKKEKKE VMEKLEESEN ELEDQTELVR DLISDVEHHL ELSTLEMLQG ANCVLRRSQS LSLQQPQTVP QKRKRTFQAP DLKGMLQVYQ GLMDIQQYWV HMTLHARNNA VIAINKEKRQ IQYRSYNTVP VSEIYHLGVL GYPALSSGKH YWEVDISRSD AWLLGLNDGK CAQPQLHSKE EMGIKKNLHS QIKQNVLFQP KCGYWVIGMK NPSVYKAFDE CSITHNSSIL VISLPDRPSR VGVFLDRKAG TLSFYDVSNC GALIYRFYDP AFPVEVYPYF NPMKCSEPMT ICGPPS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.
基因功能參考文獻：
1. E3 ligase TRIM30alpha is an important negative-feedback regulator of innate immune responses to DNA viruses by targeting STING PMID: 26114947
2. Data indicated that Trim30 and Ucp3 play pivotal roles in energy balance and glucose homeostasis and might be used as genetic markers to represent the stage of obesity during the early and late stages of adipose tissue development, respectively. PMID: 25895476
3. These results indicate a distinct requirement for TRIM30 in modulation of NF-kappaB activation and cell proliferation induced by TCR stimulation. PMID: 24756037
4. Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30alpha in a TRAF3-dependent manner. PMID: 23220069
5. TRIM30alpha is a target gene of LTbetaR signaling in bone marrow-derived macrophages LTbetaR-induced TRIM30alpha expression inhibits the production of proinflammatory cytokines & mediators upon TLR4 & TLR9 restimulation. PMID: 22357629
6. TRIM30 is a negative regulator of NLRP3 inflammasome activation and provide insights into the role of TRIM30 in maintaining inflammatory responses. PMID: 21048113
7. Tripartite-motif protein TRIM30alpha interacts with the TAB2-TAB3-TAK1 adaptor-kinase complex involved in the activation of transcription factor NF-kappaB. PMID: 18345001
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亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Highly expressed in spleen and lymph nodes (at protein level).
數據庫鏈接：

KEGG: mmu:20128

STRING: 10090.ENSMUSP00000076189

UniGene: Mm.295578