Recombinant Mouse Transcription elongation factor A protein 3 (Tcea3)

中文名稱：

小鼠Tcea3重組蛋白
貨號：

CSB-YP023271MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tcea3重組蛋白
貨號：

CSB-EP023271MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tcea3重組蛋白
貨號：

CSB-EP023271MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tcea3重組蛋白
貨號：

CSB-BP023271MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tcea3重組蛋白
貨號：

CSB-MP023271MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tcea3
Uniprot No.：

P23881
別名：

Tcea3; Tfiish; Transcription elongation factor A protein 3; Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-347
氨基酸序列

MGLEEELLRI AKKLEKMVSR KKTEGALDLL KKLNSCQMSI QLLQTTRIGV AVNGVRKHCS DKEVVSLAKV LIKNWKRLLD SPRTTKGERE EREKAKKEKG LGCSDWKPEA GLSPPRKKGG GEPKTRRDSV DSRSSTTSSP KRPSLERSNS SKSKVETPTT PSSPSTPTFA PAVCLLAPCY LTGDSVRDKC VEMLSAALKA EDNFKDYGVN CDKLASEIED HIYQELKSTD MKYRNRVRSR ISNLKDPRNP GLRRNVLSGA ISPELIAKMT AEEMASDELR ELRNAMTQEA IREHQMAKTG GTTTDLLRCS KCKKKNCTYN QVQTRSADEP MTTFVLCNEC GNRWKFC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
基因功能參考文獻：
1. Vascular endothelial growth factor A and VEGFC, major transcription factors that regulate vasculogenesis, are activated in Tcea3 knocked down mESCs PMID: 24397209
2. Tcea3 critically regulates pluripotent differentiation of mouse embryonic stem cells as a molecular rheostat of Lefty1-Nodal-Smad2 signaling. PMID: 23169579
3. S-II is required for definitive hematopoiesis. PMID: 16581793
4. These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template. PMID: 19210546
亞細胞定位：

Nucleus.
蛋白家族：

TFS-II family
組織特異性：

Liver, kidney and heart.
數據庫鏈接：

KEGG: mmu:21401

STRING: 10090.ENSMUSP00000099592

UniGene: Mm.112