Recombinant Mouse T-cell activation Rho GTPase-activating protein (Tagap)

中文名稱：

小鼠Tagap重組蛋白
貨號：

CSB-YP023104MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Tagap重組蛋白
貨號：

CSB-EP023104MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Tagap重組蛋白
貨號：

CSB-EP023104MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tagap重組蛋白
貨號：

CSB-BP023104MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tagap重組蛋白
貨號：

CSB-MP023104MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tagap
Uniprot No.：

B2RWW0
別名：

Tagap; T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區(qū)域：

1-714
氨基酸序列

MKLISSLDGS KTLNANNMET LIECQSEGDI KVPPLLTSCE SEDSICQLTE IKKRKKVLSW PSLMRKLSPS SDFSGSLEPE LKVSLFDQPL SIICGENDTL PRPIQDILTI LCLKGPSTEG IFRKAASEKA RKELKEGLNC GVSVNLKQLP VHLLAVVFKD FLRGIPLKLL SCDLFEDWMG ALEKPTEEDR IEALKQVAGG LPRPNLLLLR HLLYVLHLIS KNAEVNKMDS SNLAICIGPN MLTLKNDQSL SFQAQKDLNN KVKILVEFLI DNCFEIFGEN IRTRSRITSD DSLEHTDSSD VSTLQNDSAY DSNDPDVEPT SGAASPNRQL EGPTPTMAGL DTRGQRDTCE SSSESSVSMV VRLKSSIVQQ DRRFSEPNMS PSRECLVGPT SKQKLARSED SFTLSQDASC SEGDEAEDPF TEEVFPAVDS KPKRPVDLKI KNWTQGLASP QGHITKAFSR SSPGESLGSS PVPSPSCPKR NFFTRHQSFT TKTDKTKPQR EIRKHSMSFS FASHKKVLPR TSSIGSEKSK DFSRDQLQKD LRKESQLSGR IVQENESEIQ SQTSLGFSLS GTWALSVDNT FQLVDMRKPG SPPSYEEAIY YQTSGLTAYG GQTVGSMRSR MFKPSTAVPP VPSHHGGDLS EGTPGGHRLS SVTEHWTHSQ TVHVSIETQG RSELHQLRTV SESMQKAKLD CLGPQHSHLV FEADQLCCAR ESYI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring.
基因功能參考文獻：
1. these studies demonstrated that TAGAP was required for TH17 differentiation in vitro and that the loss of TAGAP in mice ameliorated the clinical features of experimental autoimmune encephalomyelitis, indicating that TAGAP is critical for disease progression PMID: 28462950
2. Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1 PMID: 11471064
3. t-complex responder locus, Tcr, rescues t-sperm but not +-sperm from defective products of t-complex distorter loci, Tcds PMID: 14559236
組織特異性：

Highly expressed in testis.
數(shù)據(jù)庫鏈接：

KEGG: mmu:72536

STRING: 10090.ENSMUSP00000047431

UniGene: Mm.119680