Recombinant Mouse Solute carrier family 2, facilitated glucose transporter member 1 (Slc2a1), partial
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中文名稱：小鼠Slc2a1重組蛋白
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貨號：CSB-EP021546MO-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Slc2a1; Glut1; Solute carrier family 2; facilitated glucose transporter member 1; Glucose transporter type 1; erythrocyte/brain; GLUT-1; GT1
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種屬：Mus musculus (Mouse)
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蛋白長度：Partial
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蛋白標(biāo)簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors.
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基因功能參考文獻(xiàn)：
- Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes that is essential for murine skeletal development. PMID: 30446646
- Adequate Glut1 protein is indispensable for the proper development and maintenance of the capillary network of the brain. PMID: 28106060
- GLUT1 may play an important role in Prostate Cancer progression via mediating glycolysis and proliferation. There is potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in Prostate Cancer. PMID: 29105798
- ARAP2 knockdown did not affect fatty acid uptake but reduced basal glucose uptake, total levels of the glucose transporter GLUT1, and GLUT1 levels in the plasma membrane and the lipid micro-domain fraction. PMID: 27476102
- TBC1D5 shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking. PMID: 28602638
- inhibition of GLUT1 activity and/or expression is shown to impair TGF-beta-driven fibrogenic processes, including cell proliferation and production of profibrotic mediators PMID: 27480571
- B cell leukemia-induced inhibition of T cell Akt/mTORC1 signaling and glucose metabolism drives T cell dysfunction; metabolic defects included reduced Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling, decreased expression of the glucose transporter Glut1 and hexokinase 2, and reduced glucose uptake PMID: 27511728
- This study demonstrates a strict requirement for GLUT1 in the early stages of mammary tumorigenesis in vitro and in vivo. PMID: 27998284
- GLUT1-dependent glycolysis regulates fibrogenesis in aged lung. PMID: 27997810
- Data (including data from studies using transgenic mice) suggest that Glut1 (glucose transporter type 1) is a critical downstream target of Hif1a (hypoxia-inducible factor 1, alpha subunit) mediating hyperglycemia-induced extracellular matrix accumulation in kidney via regulation of Nox4 (NADPH oxidase type 4) expression in nephropathy due to diabetes type 1. PMID: 26908870
- CRISPR/Cas9-mediated disruption of the Hdac2 gene increased Slc2a1 expression, suggesting that it is one of the responsible histone deacetylases (HDACs). These results confirm that b-OHB is a HDAC inhibitor and show that b-OHB plays an important role in fasting-induced epigenetic activation of a glucose transporter gene in the brain. PMID: 27935189
- Taken together, the data suggest that curcumin binds directly to GLUT1 at a site that overlaps with the cytochalasin B binding site and thereby inhibits glucose transport. PMID: 27039889
- overnutrition during early life induces short-term metabolic disturbances, impairment in heart insulin signaling, up-regulates GLUT-1 and switch cardiac fuel preference in juvenile mice PMID: 26608021
- alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT translocation that may be specific to the alpha(1A)-AR subtype. PMID: 26832303
- Glut1 connects the enhanced glucose uptake in atheromatous plaques of ApoE(-/-) mice with their myelopoiesis through regulation of hematopoietic stem and multipotential progenitor cell maintenance and myelomonocytic fate. PMID: 26926469
- Enhanced GLUT1 expression in melanoma cells favors their metastatic behavior. PMID: 26293674
- bright-field microscopy designed to automatically identify and segment microvessels containing the protein glucose transporter 1. PMID: 26828723
- Morphological changes and GLUT1, GLUT3, and GLUT4 expression were evaluated in placentas by immunohistochemical and image analysis and correlated with iAs and arsenical species concentration, which were quantified by atomic absorption spectroscopy PMID: 26339590
- Nicotine pre-exposure reduced the ischemic-reperfusion-enhanced glucose transporter-1 function and expression at the blood brain barrier in a focal brain ischemia mouse model. PMID: 25925411
- A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 and HK2 were observed after radiation treatment. PMID: 25304950
- Glut1 deficiency decreased Teff expansion and the ability to induce inflammatory disease in vivo. PMID: 24930970
- GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure. PMID: 24583251
- Beta 3-adrenoceptors stimulate glucose uptake in brown adipose tissue via cAMP-mediated increases in GLUT1 transcription and synthesis and mTOR complex 2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane. PMID: 25385184
- GLUT1 brain levels in scrapie-infected animals was unchanged compared to controls. PMID: 24243341
- Cysteine biochemistry is utilized in both methylene blue and berberine activation of glucose uptake by GLUT1. PMID: 24333987
- glucose transporter 1 (GLUT1)-mediated glucose metabolism has a role in the proinflammatory phenotype PMID: 24492615
- Placental endoplasmic reticulum stress by administration of Tun causes downregulation of Slc2a1(GLUT1) and upregulation of Slc2a3(GLUT3) mRNA expression. PMID: 24370435
- Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha expression, blunted mRNA expression of HIF-1alpha, VEGF, and the glucose transport protein Glut-1 was also observed. PMID: 24240089
- Quantitative real-time polymerase chain reaction revealed up-regulation of hypoxia and oxidative stress related genes, including Slc2a1. PMID: 23429070
- Access to a running wheel for 48h induced plastic changes in the expression of astrocyte GLUT1. A significant increase was found only in motor cortex, though other motor related areas showed a similar trend(sensorimotor cortex, striatum and cerebellum). PMID: 23201358
- Loss of neuronatin caused a reduction in both basal and insulin-stimulated glucose uptake and glycogen synthesis, likely mediated by a reduction in Glut1 protein upon silencing of neuronatin. PMID: 23482445
- The results of this study demonstrated that valproic acid, a known histone deacetylases inhibitor, increased the glucose transport capacity in SLC2A1 heterozygous cerebral astrocytes of mice. PMID: 22532550
- metabolite receptors (Slc2a1 and Ldr) were down-regulated in diet-induced obese mice PMID: 23001779
- Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain PMID: 23072752
- GLUT1 siRNA blocked the 6-phenyl cAMP-induced increase in embryonic stem cell proliferation. PMID: 22658979
- Report GLUT1 expression in normal left ventricle and in models of dilated and hypertophic cardiomyopathy. PMID: 22681646
- Acute fasting decreases GLUT1 expression and glucose utilisation, inhibiting the processes of oocyte maturation and cumulus cell expansion. PMID: 22697123
- Data show that an intense glucose transporter 1 (GLUT1)-immunoreaction was localized in the enamel organ of bud-stage molar tooth germs, where the active cell proliferation occurred. PMID: 22226978
- Data suggest that GnRH up-regulates expression/localization of Glut1 (but not Glut2, Glut4, or Glut8) and stimulates glucose utilization in gonadotrophs; effects of GnRH on Glut1 mRNA expression are partly mediated by ERK activation/phosphorylation. PMID: 22107955
- Studies demonstrate that GLUT1 is the major glucose transporter in mouse mammary carcinoma models overexpressing ErbB2 or PyVMT. PMID: 21826239
- GLUT1 enhances mTOR activity independently of TSC2 and AMPK. PMID: 21613414
- Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes PMID: 21846717
- Data suggest that a portion of the hypoglycemic effects of berberine can be attributed to its acute activation of the transport activity of GLUT1. PMID: 21545824
- The expression of GLUT1 in the ovary was generally weak with an intense expression of GLUT1 only in some vascular endothelia. PMID: 21360229
- Findings suggest that GLUT1 mRNA expression is essential for decidualization. PMID: 21343253
- Data show that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same was observed for CA9 and GLUT1, but not LOX, in SCCVII tumors. PMID: 21306648
- adipose-specific deletion of SCD1 induces GLUT1 up-regulation in adipose tissue, suggesting that GLUT1 may play a critical role in controlling glucose homeostasis of adipose tissue in adipose-specific SCD1-deficient conditions. PMID: 20655875
- GLUT1-VEGF-GLUT1 positive feedback loop may play a key role in contributing to renal disease in this model of nondiabetic glomerulosclerosis. PMID: 19918242
- Expression is increased by exposure to tolbutamide in embryonic heart in vitro. Effect is concentration-dependent. PMID: 11835228
- induction resulting from activation of prolyl hydroxylase oxygen-sensor PMID: 12649278
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment.
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蛋白家族：Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
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組織特異性：Retina (at protein level).
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