Recombinant Mouse Ski-like protein (Skil)

中文名稱：

小鼠Skil重組蛋白
貨號(hào)：

CSB-YP723333MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Skil重組蛋白
貨號(hào)：

CSB-EP723333MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Skil重組蛋白
貨號(hào)：

CSB-EP723333MO-B
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Skil重組蛋白
貨號(hào)：

CSB-BP723333MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Skil重組蛋白
貨號(hào)：

CSB-MP723333MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Skil
Uniprot No.：

Q60665
別名：

Skil; Skir; Sno; Ski-like protein; Ski-related oncogene; Ski-related protein
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-675
氨基酸序列

MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH LDDYGDASVE PDGEHAKRNR VSLPETLNLN PSLKHTLAQF HLSSQSSLGG PAAFSARYSQ ESMSPTVFLP LPSPQVLPGP LLIPSDSSTE LTQTLLEGES ISCFQVGGEK RLCLPQVLNS VLREFSLQQI NTVCDELYIY CSRCTSDQLH ILKVLGILPF NAPSCGLITL TDAQRLCNAL LRPRTFPQNG SILPAKSSLA QLKETGSAFE VEHECLGKCQ GLFAPQFYVQ PDAPCIQCLE CCGMFAPQTF VMHSHRSPDK RTCHWGFESA KWHCYLHVNQ KYLGTPEEKK LKIILEEMKE KFSMRNGKRI QSKTDTPSGM ELPSWYPVIK QEGDHVPQTH SFLHPSYYLY MCDKVVAPNV SLTSAASQSK EATKAETSKS TSKQSEKPHE SSQHQKTVSY PDVSLEEQEK MDLKTSRELY SCLDSSISNN STSRKKSESA VCSLVRGTSK RDSEDSSPLL VRDGEDDKGK IMEDVMRTYV RQQEKLNSIL QRKQQLQMEV EMLSSSKAMK ELTEEQQNLQ KELESLQSEH AQRMEEFYIE QRDLEKKLEQ VMQQKCTCDS TLEKDREAEY AAQLAELRQR LDHAEADRQE LQDELRQERE ARQKLEMMIK ELKLQIGKSS KPSKD
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May have regulatory role in cell division or differentiation in response to extracellular signals.
基因功能參考文獻(xiàn)：
1. Loss of SnoN is associated with partial embryonic lethality, mostly due to defects in angiogenesis in both the yolk sac and embryo body PMID: 24019535
2. SnoN mediates a negative feedback mechanism evoked by TGF-beta to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes. PMID: 22767605
3. SnoN, a negative regulator of TGF-beta signaling, coordinates TGF-beta and prolactin signaling to control alveologenesis and lactogenesis. PMID: 22833129
4. mRNA for positive regulators of Fshb expression, such as Fos and Jun, were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the corepressors Skil, Crem, and Tgif1. PMID: 21659477
5. The endogenous SnoN plays a role in regulating ADAM12 expression in response to TGFbeta1. PMID: 20457602
6. The authors conclude that somatic and germ cells at all differentiation stages are actively transducing TGFbeta superfamily signals but that responses to these ligands may be selectively modulated by SnoN2. PMID: 19526521
7. Sno is a significant negative regulator of antiproliferative TGF-beta signaling in both T cells and other cell types in vivo PMID: 12861029
8. SnoN is directly regulated by sumoylation leading to the enhancement of the ability of SnoN to repress transcription in a promoter-specific manner PMID: 16966324
9. SnoN plays both pro-tumorigenic and antitumorigenic roles at different stages of mammalian malignant progression PMID: 17074815
10. Arkadia induces degradation of SnoN and c-Ski in addition to Smad7. PMID: 17510063
11. SnoN plays an essential role in AFP repression by positively regulating mSin3A protein levels. p53 and SnoN are both needed to recruit the mSin3A corepressor. PMID: 18212064
12. These data indicate that SnoN is expressed in a cell-specific manner during ovarian follicular development, atresia, and luteinization and that SnoN might play essential roles in these physiological processes. PMID: 19267613
13. SnoN functions as a tumour suppressor by inducing premature senescence. PMID: 19745809
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蛋白家族：

SKI family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:20482

STRING: 10090.ENSMUSP00000029194

UniGene: Mm.15406