Recombinant Mouse Selenocysteine lyase (Scly)

中文名稱：

小鼠Scly重組蛋白
貨號：

CSB-YP020827MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Scly重組蛋白
貨號：

CSB-EP020827MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Scly重組蛋白
貨號：

CSB-EP020827MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Scly重組蛋白
貨號：

CSB-BP020827MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Scly重組蛋白
貨號：

CSB-MP020827MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scly
Uniprot No.：

Q9JLI6
別名：

Scly; Scl; Selenocysteine lyase; mSCL; EC 4.4.1.16
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-432
氨基酸序列

MDAARNGALG SVESLPDRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS SSYVSGRKAK DIINAARASL AKMIGGKPQD IIFTSGGTES NNLVIHSMVR CFHEQQTLKG NMVDQHSPEE GTRPHFITCT VEHDSIRLPL EHLVENQMAE VTFVPVSKVN GQAEVEDILA AVRPTTCLVT IMLANNETGV IMPVSEISRR IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF LTIVGHKFYG PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI QGSQLQGYTV LAQCRTLLAS VGASCHSNHE DRPSPVLLSC GIPVDVARNA VRLSVGRGTT RADVDLIVQD LKQAVAQLEG RL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
基因功能參考文獻：
1. Selenocysteine lyase regulates energy metabolism via the hypothalamus. PMID: 29385050
2. our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly PMID: 23811004
3. The results suggested a dependence of glucose and lipid homeostasis on selenocysteine lyase activity. These findings connect Se and energy metabolism and demonstrate for the first time a unique physiological role of selenocysteine lyase. PMID: 22890841
4. Scly knockout mice do not display neurological dysfunction comparable to Sepp1 knockout mice. PMID: 22487427
亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

Class-V pyridoxal-phosphate-dependent aminotransferase family
組織特異性：

Widely expressed. Present in liver, kidney, testis (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:50880

STRING: 10090.ENSMUSP00000027532

UniGene: Mm.25724