Recombinant Mouse SPARC (Sparc)
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中文名稱：小鼠Sparc重組蛋白
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貨號：CSB-EP022486MO-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Sparc; SPARC; Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine
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種屬：Mus musculus (Mouse)
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蛋白長度：Full Length of Mature Protein
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表達(dá)區(qū)域：18-302
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氨基酸序列APQ QTEVAEEIVE EETVVEETGV PVGANPVQVE MGEFEDGAEE TVEEVVADNP CQNHHCKHGK VCELDESNTP MCVCQDPTSC PAPIGEFEKV CSNDNKTFDS SCHFFATKCT LEGTKKGHKL HLDYIGPCKY IAPCLDSELT EFPLRMRDWL KNVLVTLYER DEGNNLLTEK QKLRVKKIHE NEKRLEAGDH PVELLARDFE KNYNMYIFPV HWQFGQLDQH PIDGYLSHTE LAPLRAPLIP MEHCTTRFFE TCDLDNDKYI ALEEWAGCFG IKEQDINKDL VI
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蛋白標(biāo)簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
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基因功能參考文獻(xiàn)：
- It is a matricellular glycol that regulates cell proliferation, tissue repair, and tumorigenesis and a potential therapeutic target for conditions involving intestinal inflammation. PMID: 28582593
- Sparc levels in tendons are critical for proper collagen fibril maturation. PMID: 27586416
- miR-29 directly targeted SPARC, resulting in degradation of SPARC-encoding mRNA and reduction in the SPARC protein level. PMID: 29462611
- SPARC plays a crucial role in the proliferation and differentiation of C2C12 and may be involved in the link between the ECM remodeling and mitochondrial func PMID: 29420632
- SPARC is regulating the interplay between myeloid-derived suppressor cells and the extracellular matrix to drive the induction of epithelial-to-mesenchymal transition in tumor cells. PMID: 27681434
- The results demonstrate for the first time a functional role of the N-propeptide in regulating collagen fiber assembly and cell behavior and suggest that SPARC and the N-propeptide of collagen I have distinct activities in regulating collagen fiber assembly and fibroblast function. PMID: 28245286
- SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved. PMID: 28122087
- An ADAMTS1 blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 interaction. In conclusion, ADAMTS1 is an important mediator of SPARC-regulated cardiac aging. PMID: 27143554
- SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function PMID: 27908613
- resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas. PMID: 27099155
- SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC migration. PMID: 26381424
- SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression. PMID: 26169969
- SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues. PMID: 25827352
- Tumor-produced SPARC and VCAM1 are regulators of cancer extravasation. PMID: 25925867
- The results of this study indicated that the loss of p53 by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance. PMID: 24862407
- This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function. PMID: 22950524
- SPARC has a significant role in the development of concanavalin A -induced severe liver injury. PMID: 25410742
- SPARC acts as an important mediator of age-related cardiac inflammation by increasing the expression of macrophage M1 markers and decreasing M2 markers. PMID: 25877699
- SPARC inhibits growth factor-induced signaling in both INS-1 beta cells and primary mouse islets, and inhibits IGF-1-induced proliferation of INS-1 beta cells. PMID: 25204658
- Age and SPARC change the extracellular matrix composition of the left ventricle. PMID: 24783223
- findings suggest that SPARC plays a crucial role in the regulation of early B lymphopoiesis. PMID: 24598056
- SPARC-deficient mice display higher resistance to serial treatment with the chemotherapeutic agent 5-fluorouracil (5-FU). PMID: 24833352
- effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts PMID: 24223185
- SPARC KO mice had less inflammation. PMID: 24204877
- These results demonstrate that there is a delicate temporal regulation of SPARC and that disturbances in this may have an adverse effect on muscle regeneration. PMID: 23670848
- These findings suggest that SPARC plays a critical role in the maintenance of miMEFs without loss of cell number and might be a key component for supporting the culture of human PSCs. PMID: 23661086
- Loss of SPARC not only upregulates atrogin 1 expression but also enhances transforming growth factor (TGF)beta signaling, which may in turn cause muscle atrophy. PMID: 23424163
- data suggest that SPARC plays a significant role in liver fibrogenesis. Interventions to inhibit SPARC expression are suggested as promising approaches for liver fibrosis treatment PMID: 23408952
- new insight into the biological functions of SPARC PMID: 23349702
- These findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis. PMID: 22851666
- SPARC modulates intraocular pressure regulation in the eye, and also correlates with trabecular meshwork morphology. PMID: 23422826
- Using a chemical carcinogenesis model in Sparc-deficient mice and their wild-type littermates, we found that loss of SPARC accelerated the development of urothelial preneoplasia, neoplasia, and metastasis and was associated with decreased survival. PMID: 23321672
- This sdtudy demonistrated that SPARC regulates microgliosis and functional recovery following cortical ischemia and brain injury. PMID: 23467362
- SPARC and SC1 may share significant homology but are likely to have distinct but complementary roles in central nervous system development. PMID: 22173850
- SPARC-null mice develop region-specific, age-dependent hypersensitivity to cold, icilin, and capsaicin; axial discomfort; motor impairment; and reduced physical function. PMID: 22414871
- SPARC suppresses angiogenesis of gastric cancer by down-regulating the expression of VEGF and MMP-7 PMID: 22957090
- Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion. PMID: 22955913
- SPARC promotes the development of erythroid progenitors, but does not affect terminal erythroid differentiation. PMID: 22687753
- The Sparc(-/-) mice had reduced survival and fewer well-defined abdominal lesions compared with WT controls after IP injection, whereas no differences were observed in survival or abdominal lesions between Sparc(-/-) and WT mice after OT injection. PMID: 22003835
- Osteonectin may suppress prostate cancer pathogenesis. PMID: 22525512
- aberrant TGFbeta1-activation in the absence of host SPARC contributes significantly to tumor progression and SPARC, by controlling ECM deposition and maturation, can regulate TGFbeta availability and activation PMID: 22348081
- SPARC influences the shuttling of Pax6 via the TGF-beta/Smad signaling pathway. PMID: 22539874
- follicular dendritic cell networking toward Th17 responses PMID: 21962567
- Data indicate that intracellular SPARC-positive vesicles did not undergo visible degradation. PMID: 21949685
- SPARC and connective tissue growth factor appeared to be involved in the same biological pathway PMID: 21978691
- DNA methylation down-regulates SPARC expression in chronic low back pain (LBP) in pre-clinical models and in patients with chronic LBP. PMID: 21867537
- SPARC regulates collagen in the heart by modulating procollagen processing and interactions with fibroblast cell surfaces. PMID: 21666116
- These results identify hevin as a positive and SPARC as a negative regulator of synapse formation. PMID: 21788491
- SPARC deletion preserves left ventricular function at day 3 post-myocardial infarction but may be detrimental for the long-term response due to impaired fibroblast activation. PMID: 21602472
- SPARC promotes pericyte migration by diminishing TGF-beta activity and identify a novel function for endoglin in controlling pericyte behavior. PMID: 21708981
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.
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蛋白家族：SPARC family
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