Recombinant Mouse SH2B adapter protein 3 (Sh2b3)

中文名稱：

小鼠Sh2b3重組蛋白
貨號：

CSB-YP021208MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Sh2b3重組蛋白
貨號：

CSB-EP021208MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Sh2b3重組蛋白
貨號：

CSB-EP021208MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sh2b3重組蛋白
貨號：

CSB-BP021208MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sh2b3重組蛋白
貨號：

CSB-MP021208MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sh2b3
Uniprot No.：

O09039
別名：

Sh2b3; Lnk; SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-548
氨基酸序列

MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH PQPPRADLVS LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP ACALQHLRRG LRQLFRRRSA GELPGATSDT NDIDTTAASR PGPARKLLPW GLREPPTEAL KEVVLRYSLA DEAAMDSGAR WQRGRLVLRS PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM PDNLYTFVLK VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL ECGAACDVRL SGYVVVLSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSVGC PPSHGAEALP GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
基因功能參考文獻：
1. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype PMID: 28067429
2. Specific targeting of Lnk may be a promising EPC-based therapeutic strategy for dermal wound healing. PMID: 27793180
3. The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction. PMID: 28526415
4. We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion. PMID: 25882670
5. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure. PMID: 26101343
6. Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension. PMID: 25664851
7. Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues. PMID: 25024389
8. results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction. PMID: 24536025
9. Report that Lnk siRNA-transfected endothelial commitment of c-kit+/Sca-1+/lineage bone marrow cells have high hematopoietic stem/endothelial progenitor cells (EPCs) colony-forming capacity exhibiting endothelial markers, VE-Cad, VEGF and Ang-1. PMID: 23897412
10. Lnk deficiency partially mitigates hematopoietic stem cell aging. PMID: 22812478
11. that the SH2B3 mutation is absent in NOD mice. To our knowledge, this is the first report of the sequence and the protein levels of SH2B3 in NOD mice PMID: 22614355
12. LNK as a stroke-specific, endogenous negative regulator of neural stem and progenitor cell proliferation PMID: 22496561
13. Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL. PMID: 22101255
14. Loss of Foxo3 causes a myeloproliferative syndrome with increased intracellular ROS, overactive intracellular signalling through the AKT/mTOR signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling. PMID: 21113129
15. the loss of Lnk signaling enhances the regenerative response during fracture healing PMID: 20855498
16. Lnk binds to c-Fms and can blunt M-CSF stimulation PMID: 20571037
17. Findings suggest that Lnk deletion reinforces the commitment of KSL cells to EPCs, promoting subsequent repair of injured spinal cord through the acceleration of angiogenesis and astrogliosis. PMID: 19859984
18. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. PMID: 20038804
19. Lnk plays critical roles in the expansion and function of early hematopoietic progenitors PMID: 11805142
20. Lnk overexpression in transgenic mice results in impaired expansion of lymphoid precursor cells and altered mature B cell subpopulations. PMID: 12517931
21. regulates production of B cells and hematopoietic stem cells--review PMID: 12518435
22. Lnk is a negative regulator of hematopoiesis in the aorta-gonad-mesonephros region PMID: 14612394
23. Lnk, SH2-B, and APS have roles in mast cell development, growth, and functions PMID: 14766215
24. Lnk negatively modulates mpl-tpo signaling pathways PMID: 15337790
25. Transient inhibition of Lnk or Lnk-mediated pathways could be a potent approach to augment engraftment of hematoopietic stem cells/hematopoietic progenitor cells. PMID: 16332975
26. Lnk-deficient HSCs are hypersensitive to TPO; Competitive repopulation revealed that long-term repopulating activity increases in Lnk-deficient HSCs, but not in WT HSCs, when these cells are cultured in the presence of TPO with or without stem cell factor PMID: 17284614
27. Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. PMID: 17693582
28. contact of MKs with adhesion molecules via integrins might contribute to platelet release, which is under Lnk-mediated regulation of Stat-5 activation PMID: 18456388
29. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. PMID: 18618018
30. suggest pivotal role of lnk adaptor protein in endothelial progenitor cell biology for vascular regeneration. PMID: 19325148
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蛋白家族：

SH2B adapter family
數據庫鏈接：

KEGG: mmu:16923

STRING: 10090.ENSMUSP00000041611

UniGene: Mm.65493