Recombinant Mouse Repulsive guidance molecule A (Rgma)

中文名稱：

小鼠Rgma重組蛋白
貨號：

CSB-YP754243MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rgma重組蛋白
貨號：

CSB-EP754243MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rgma重組蛋白
貨號：

CSB-EP754243MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rgma重組蛋白
貨號：

CSB-BP754243MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rgma重組蛋白
貨號：

CSB-MP754243MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rgma
Uniprot No.：

Q6PCX7
別名：

Rgma; Repulsive guidance molecule A; RGM domain family member A
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

170-427
氨基酸序列

P HLRTFTDHFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSA ATATSKLTII FKNFQECVDQ KVYQAEMDEL PSAFADGSKN GGDKHGANSL KITEKVSGQH VEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC PLNQQIDFQA FRANAESPRR PAAASPSPVV PETFPYETAV AKCKEKLPVE DLYYQACVFD LLTTGDVNFT LAAYYALEDG KMLHSNKDKL HLFERTRELP GAVAAAA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
基因功能參考文獻：
1. promotes dendritic cell maturation PMID: 26896667
2. RGMa is involved in Th17-cell-mediated neurodegeneration. PMID: 25456136
3. repulsive RGMa-Neogenin interactions drive interneurons into the migratory corridor PMID: 24312340
4. Postnatal spiral ganglion neurons retain capacity to send out processes that respond to signals for synaptogenesis, but postnatal RGMa expression appears to be detrimental to regeneration of afferent hair cell innervation and antagonizes synaptogenesis PMID: 24123853
5. RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways. PMID: 23275173
6. RGMa enhances CD4+ T cell activation facilitating central nervous system intervention in an animal model of multiple sclerosis presented in this review. PMID: 22183806
7. Loss-of-function analysis in mice revealed that RGMa may play a more important role in neural tube morphogenesis. PMID: 22568948
8. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
9. activated microglia play a major role in inhibiting axon regeneration via RGMa PMID: 21957482
10. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
11. Neutralizing antibodies to RGMa attenuated clinical symptoms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and reduced invasion of inflammatory cells into the CNS. PMID: 21423182
12. Our data indicate an important role of RGMa for the layer-specific termination of the perforant pathway as a repulsive signal that compels entorhinal fibers to stay in their correct target zone PMID: 15084667
13. a role for RGMa as a bone morphogenic protein co-receptor. PMID: 15975920
14. RGMa-mediated neogenin signal transduction pathway involved in axonal guidance. PMID: 17389603
15. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
16. RGMa may negatively regulate neuronal network formation in cortical neurons. PMID: 18519029
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Repulsive guidance molecule (RGM) family
組織特異性：

Expressed in gradient in periventricular layers of the developing nervous system. In adult, expressed in scattered cells throughout the brain.
數據庫鏈接：

KEGG: mmu:244058

STRING: 10090.ENSMUSP00000091870

UniGene: Mm.333943