Recombinant Mouse Ras GTPase-activating protein SynGAP (Syngap1), partial

中文名稱：

小鼠Syngap1重組蛋白
貨號：

CSB-YP023010MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Syngap1重組蛋白
貨號：

CSB-EP023010MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Syngap1重組蛋白
貨號：

CSB-EP023010MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Syngap1重組蛋白
貨號：

CSB-BP023010MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Syngap1重組蛋白
貨號：

CSB-MP023010MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Syngap1
Uniprot No.：

F6SEU4
別名：

Syngap1; Ras/Rap GTPase-activating protein SynGAP; Neuronal RasGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
基因功能參考文獻：
1. Study results indicate that Syngap1 plays a critical role in GABAergic circuit function and further suggest that Syngap1 haploinsufficiency in GABAergic circuits may contribute to cognitive deficits. PMID: 27827368
2. The authors present evidence that synGAP-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ domains of PSD-95. PMID: 27623146
3. Study found that Syngap1 mutations associated with developmental brain disorders disrupt a critical period of neuronal growth, maturation, and dynamics of dendritic structures known to influence de novo assembly of developing cortical circuits PMID: 25444158
4. inactivation of a single copy of syngap1 induced widespread early functional maturation of excitatory connections in the mouse neocortex PMID: 23785156
5. These data demonstrate that SynGAP protein acts as a critical developmental repressor of neural excitability that promotes the development of life-long cognitive abilities. PMID: 23141534
6. This study demonstrated the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR and hippocampal integrity. PMID: 22700469
7. Overexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and increasing miniature excitatory synaptic currents amplitude/frequency, respectively. PMID: 22692543
8. SynGAP is an important regulator of the release of the neuropeptide calcitonin gene-related peptide from primary sensory neurons and can modulate capsaicin-induced hypernociception. PMID: 21525372
9. Data show that deletion of SynGAP is associated with notable behavioral as well as morphological phenotypes indicative of hippocampal dysfunction. PMID: 20105235
10. The GAP activity of synGAP and its association with PSD-95 are important for normal regulation of spine and synapse formation in hippocampal neurons. PMID: 15470153
11. SynGAP expression peaked at times of synaptogenesis and developmental plasticity and SynGAP showed a more spatially restricted pattern as illustrated by its restriction to forebrain PMID: 15673435
12. The level of synGAP protein measured at 2 and 8 weeks after birth indicates that neuronal apoptosis is enhanced by reduction of synGAP in conditional mice mutants. PMID: 15733080
13. SynGAP, a synaptic Ras GTPase activating protein, is essential for the anatomical development of whisker-related patterns in the developing somatosensory pathways in rodent forebrain. PMID: 16452659
14. SynGAP plays a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. PMID: 16537406
15. synGAP mediates a rate-limiting step in steady-state regulation of spine morphology PMID: 19074040
16. The syngap mutant mice displayed a complete lack of social memory and SynGAP mutants had deficits in cued fear conditioning and working memory, indicating abnormal function of circuits that control emotion and choice. PMID: 19145222
17. constitutive SynGAP reduction increases vigor in the execution of learned operant behavior without compromising its temporal control, yielding effects readily distinguishable from NMDAR blockade. PMID: 19824778
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亞細胞定位：

Membrane; Peripheral membrane protein. Cell junction, synapse.
數據庫鏈接：

KEGG: mmu:240057

STRING: 10090.ENSMUSP00000080038

UniGene: Mm.328888