Recombinant Mouse Ran-binding protein 9 (Ranbp9)

中文名稱：

小鼠Ranbp9重組蛋白
貨號：

CSB-YP019317MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ranbp9重組蛋白
貨號：

CSB-EP019317MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ranbp9重組蛋白
貨號：

CSB-EP019317MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ranbp9重組蛋白
貨號：

CSB-BP019317MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ranbp9重組蛋白
貨號：

CSB-MP019317MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ranbp9
Uniprot No.：

P69566
別名：

Ranbp9; Ranbpm; Ran-binding protein 9; RanBP9; B-cell antigen receptor Ig beta-associated protein 1; IBAP-1; Ran-binding protein M; RanBPM
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-653
氨基酸序列

MSGQPPPPPP QQQPPPPPPP ASAAAPATAP PGLAVGPGPA AGVPVPGLAA GSSAAAPFPH GDSALNEQEK ELQRRLKRLY PAVDEQETPL PRSWSPKDKF SYIGLSQNNL RVHYKGHGKT PKDAASVRAT HPIPAACGIY YFEVKIVSKG RDGYMGIGLS AQGVNMNRLP GWDKHSYGYH GDDGHSFCSS GTGQPYGPTF TTGDVIGCCV NLINNTCFYT KNGHSLGIAF TDLPPNLYPT VGLQTPGEVV DANFGQHPFV FDIEDYMREW RTKIQAQIDR FPIGDREGEW QTMIQKMVSS YLVHHGYCAT AEAFARSTDQ TVLEELASIK NRQRIQKLVL AGRMGEAIET TQQLYPSLLE RNPNLLFTLK VRQFIEMVNG TDSEVRCLGG RSPKSQDSYP VSPRPFSSPS MSPSHGMSIH SLAPGKSSTA HFSGFESCSN GVISNKAHQS YCHSKHQLSS LTVPELNSLN VSRSQQVNNF TSNDVDMETD HYSNGVGETS SNGFLNGSSK HDHEMEDCDT EMEVDCSQLR RQLCGGSQAA IERMIHFGRE LQAMSEQLRR ECGKNTANKK MLKDAFSLLA YSDPWNSPVG NQLDPIQREP VCSALNSAIL ETHNLPKQPP LALAMGQATQ CLGLMARSGV GSCAFATVED YLH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
基因功能參考文獻：
1. this study shows that RanBPM regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells PMID: 27835883
2. Results showed that RANBP9 is involved in alternative splicing by interacting with CLOCK during murine spermatogenesis. PMID: 29126923
3. the role of RanBP9 in the brain PMID: 23840553
4. A novel role of Ranbp9 in regulating alternative splicing in spermatogenic cells, which is critical for normal spermatogenesis and male fertility. PMID: 25474150
5. The B-cell antigen receptor integrates adaptive and innate immune signals. PMID: 26371314
6. Data found that endogenous RanBP9 positively regulates SSH1 levels and mediates Abeta-induced translocation of cofilin to mitochondria and induction of cofilin-actin pathology in cultured cells, primary neurons, and in vivo PMID: 25741591
7. RanBP9 overexpression in APDeltaE9 mouse model of Alzheimer's disease further exacerbated the reductions in spine density in both the cortex and the hippocampus PMID: 24892886
8. results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells PMID: 24312406
9. RanBP9 overexpression in transgenic mice led to striking reduction in the levels of spinophilin. PMID: 23764848
10. RanBP9 physically interacts with the tumor suppressor p73 and increases endogenous p73alpha levels at both transcriptional and post-translational levels. PMID: 23348590
11. RanBP9-cofilin pathway as critical therapeutic targets not only for stemming Abeta generation but also antagonizing Abeta-induced neurotoxicity. PMID: 22361682
12. increased Abeta levels by RanBP9 observed in the present study provides compelling evidence that RanBP9 may indeed play a key role in the etiology of AD PMID: 22294787
13. show that RanBPM is essential for normal gonad development as both male and female RanBPM(-/-) mice are sterile PMID: 21561988
14. Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor. PMID: 20829363
15. RanBPM is the enzymic substrate for USP11 and is deubiquitinated specifically PMID: 12084015
16. Using yeast two-hybrid systems, RanBPM was identified as a binding partner of p75(NTR). PMID: 12963025
17. Data show that RanBPM and mouse vasa homolog (Mvh) are closely associated with perinuclear RNA-protein complexes and chromatoid bodies, and suggests a functional relationship between translational regulation and microtubule nucleation during meiosis. PMID: 14648869
18. RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways PMID: 14722085
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亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
蛋白家族：

RANBP9/10 family
組織特異性：

Ubiquitously expressed, with highest levels in maturating spermatocytes.
數據庫鏈接：

KEGG: mmu:56705

STRING: 10090.ENSMUSP00000130636

UniGene: Mm.148781