Recombinant Mouse Radixin (Rdx)

中文名稱：

小鼠Rdx重組蛋白
貨號：

CSB-YP019532MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rdx重組蛋白
貨號：

CSB-EP019532MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rdx重組蛋白
貨號：

CSB-EP019532MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rdx重組蛋白
貨號：

CSB-BP019532MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rdx重組蛋白
貨號：

CSB-MP019532MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rdx
Uniprot No.：

P26043
別名：

Rdx; Radixin; ESP10
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-583
氨基酸序列

MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LRQIEEQTVK AQKELEEQTR KALELEQERQ RAKEEAERLD RERRAAEEAK SAIAKQAADQ MKNQEQLAAE LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP PTENEHDEQD ENSAEASAEL SSEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
基因功能參考文獻：
1. LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia. PMID: 28893864
2. identification of radixin as a PRG-2 interaction partner and showing that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2 PMID: 27641493
3. This study describes a novel mechanism that regulates plasma receptor pools in the control of synaptic receptor density. PMID: 25891999
4. The specific location of radixin-positive cells in the peri-infarct region and in microglia suggests a role for radixin in microglial activation after stroke. PMID: 23440885
5. Radixin inactivation causes hyperbilirubinemia (likely due to a defect in the localization Multidrug resistance protein 2 in the bile canalicular membranes) and deafness due to progressive degeneration of cochlear stereocilia. (Review) PMID: 21343695
6. The expression pattern demonstrated here suggests a role for radixin in neuronal migration and differentiation in the adult RMS. PMID: 20109539
7. Rdx is the dominant ERM protein in the liver of wildtype mice and is concentrated in bile canalicular membranes. Rdx(-/-) mice are normal at birth, but their bilirubin serum concentrations increase at ca. 4 weeks, with mild liver injury at 8 weeks. PMID: 12068294
8. Data report the crystal structure of the radixin FERM (4.1 and ERM) domain complexed with the intercellular adhesion molecule-2 (ICAM-2) cytoplasmic peptide. PMID: 12554651
9. Key structural and biological properties of the radixin alpha-domain (residues 311-469) are described and its role established in the conformational activation of the ezrin-radixin-moesin family of proteins. PMID: 14529273
10. cross talk between the blastocyst and uterus involving the ezrin/radixin/moesin (ERM) proteins and ERM-associated cytoskeletal cross-linker proteins CD43, CD44, ICAM-1, and ICAM-2 PMID: 14613898
11. radixin has a role in preventing progressive degeneration of cochlear stereocilia and deafness PMID: 15314067
12. Radixin binds to the cytoplasmic tail of adhesion molecules in the formation of the membrane-associated cytoskeleton. The binding site is located in the FERM (4.1 and ERM) domain. PMID: 16582480
13. Radixin knockout increases Mrp3 expression. PMID: 17204408
14. In inner ear hair cells, Rdx was enriched in stereocilia. Rdx KO mice exhibited deafness with degenerating stereocillia, but no vestibular dysfunction. In Rdx KO mice, ezrin appeared to compensate for Rdx deficiency of vestibular stereocilia. PMID: 15314067
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亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
數據庫鏈接：

KEGG: mmu:19684

STRING: 10090.ENSMUSP00000000590

UniGene: Mm.245746