Recombinant Mouse Protein kinase C-binding protein NELL2 (Nell2)

中文名稱：

小鼠Nell2重組蛋白
貨號：

CSB-YP733778MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Nell2重組蛋白
貨號：

CSB-EP733778MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Nell2重組蛋白
貨號：

CSB-EP733778MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nell2重組蛋白
貨號：

CSB-BP733778MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nell2重組蛋白
貨號：

CSB-MP733778MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nell2
Uniprot No.：

Q61220
別名：

Nell2; Mel91; Protein kinase C-binding protein NELL2; MEL91 protein; NEL-like protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

25-819
氨基酸序列

LGVDPS LQIDVLTELE LGESTDGVRQ VPGLHNGTKA FLFQESPRSI KASTATAERF FQKLRNKHEF TILVTLKQIH LNSGVILSIH HLDHRYLELE SSGHRNEIRL HYRSGTHRPH TEVFPYILAD AKWHKLSLAF SASHLILHID CNKIYERVVE MPSTDLPLGT TFWLGQRNNA HGYFKGIMQD VHVLVMPQGF IAQCPDLNRT CPTCNDFHGL VQKIMELQDI LSKTSAKLSR AEQRMNRLDQ CYCERTCTVK GTTYRESESW TDGCKNCTCL NGTIQCETLV CPAPDCPPKS APAYVDGKCC KECKSTCQFQ GRSYFEGERN TVYSSSGMCV LYECKDQTMK LVENIGCPPL DCPESHQIAL SHSCCKVCKG YDFCSEKHTC MENSVCRNLN DRAVCSCRDG FRALREDNAY CEDIDECAEG RHYCRENTMC VNTPGSFMCI CKTGYIRIDD YSCTEHDECL TNQHNCDENA LCFNTVGGHN CVCKPGYTGN GTTCKAFCKD GCRNGGACIA ANVCACPQGF TGPSCETDID ECSEGFVQCD SRANCINLPG WYHCECRDGY HDNGMFAPGG ESCEDIDECG TGRHSCTNDT ICFNLDGGYD CRCPHGKNCT GDCVHEGKVK HTGQIWVLEN DRCSVCSCQT GFVMCRRMVC DCENPTVDLS CCPECDPRLS SQCLHQNGET VYNSGDTWVQ DCRQCRCLQG EVDCWPLACP EVECEFSVLP ENECCPRCVT DPCQADTIRN DITKTCLDEM NVVRFTGSSW IKHGTECTLC QCKNGHLCCS VDPQCLQEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for neuron survival through the modulation of MAPK pathways. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty.
基因功能參考文獻：
1. Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1. PMID: 25450684
2. These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose. PMID: 26586761
3. NELL2 plays an important role in the regulation of neuronal differentiation via control of N-cadherin expression and cell aggregation. PMID: 24465772
4. Nel interacts with a range of molecules through its different domains and exerts distinct functions. PMID: 22157752
5. the NELL2 gene is trans-activated by E2 and contributes to mediating the survival promoting effects of E2 via intracellular signaling pathway of ERK PMID: 20538601
6. NELL2 plays an important role as a novel suppressor in long-term potentiation in vivo in the mouse dentate gyrus PMID: 15094495
7. NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2. PMID: 15988128
顯示更多

收起更多
亞細胞定位：

Secreted.
數據庫鏈接：

KEGG: mmu:54003

STRING: 10090.ENSMUSP00000074751

UniGene: Mm.3959