Recombinant Mouse Protein Wnt-2 (Wnt2)

中文名稱：

小鼠Wnt2重組蛋白
貨號：

CSB-YP026133MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Wnt2重組蛋白
貨號：

CSB-EP026133MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Wnt2重組蛋白
貨號：

CSB-BP026133MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Wnt2重組蛋白
貨號：

CSB-MP026133MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Wnt2
Uniprot No.：

P21552
別名：

Wnt2; Irp; Wnt-2; Protein Wnt-2; INT-1-related protein; IRP
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

26-360
氨基酸序列

SWWYM RATGGSSRVM CDNVPGLVSR QRQLCHRHPD VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV FAITRACSQG ELKSCSCDPK KKGSAKDSKG TFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG TGFTVANKRF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA PKSADWATPT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.
基因功能參考文獻：
1. Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin nuclear accumulation. PMID: 27211212
2. Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant. PMID: 27622936
3. Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis. PMID: 26556479
4. We propose that the WNT2/CTNNB1 pathway regulates CX43 expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 stability and localization in adherens junctions PMID: 23843235
5. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung PMID: 22949635
6. Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo. PMID: 22763454
7. Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells. PMID: 22146296
8. show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10 PMID: 21704027
9. Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development. PMID: 21034933
10. The canonical WNT signaling pathway is intact in mouse granulosa cells and that WNT2 can act through beta-catenin, likely downstream of FZD9, to regulate DNA synthesis. PMID: 20107203
11. Results identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development. PMID: 20018874
12. Wnt2 works in a feedforward transcriptional loop with Gata6 to regulate posterior cardiac development. PMID: 20159597
13. Upregulation by GATA6 in differentiating embryonal carcinoma cells is mediated by the direct binding of GATA-factor(s) to the Wnt2 promoter, suggesting Wnt2 is an immediate downstream target of GATA-factor regulation during early cardiogenesis. PMID: 16621466
14. Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies PMID: 17098737
15. FMR1, MECP2, and WNT2 expression were drastically down regulated in the Fragile X mouse brain. PMID: 19138667
16. Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. PMID: 19185060
17. Data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut. PMID: 19686689
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亞細胞定位：

Secreted, extracellular space, extracellular matrix. Secreted.
蛋白家族：

Wnt family
組織特異性：

In embryos in the developing allantois, pericardium heart, and ventral-lateral mesoderm; in adults in lung, brain, heart and placenta.
數據庫鏈接：

KEGG: mmu:22413

STRING: 10090.ENSMUSP00000010941

UniGene: Mm.33653