Recombinant Mouse Protein DEK (Dek)

^{In
Stock}

文獻引用 (2)

中文名稱：

Recombinant Mouse Protein DEK(Dek)
品名簡稱：

Recombinant Mouse Dek protein
貨號：

CSB-BP766504MO
說明書：

MSDS Datasheet
規格：

￥3168
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Dek
Uniprot No.：

Q7TNV0
別名：

DekProtein DEK
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length
來源：

Baculovirus
分子量：

45.7 kDa
表達區域：

1-380aa
氨基酸序列

MSAAAAPAAEGEDAPVPPSSEKEPEMPGPREESEEEEEDDEDDDEEDEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTVTQGKGQKLCEIERIHFFLSKKKPDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSTQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKSSSKGSKKERNSSGTTRKSKQTKCPEILSDESSSDEDEKKNKEESSEDEEKESEEEQPPKKTSKKEKAKQKATAKSKKSVKSANVKKADSSTTKKNQKSSKKESESEDSSDDEPLIKKLKKPPTDEELKETVKKLLADANLEEVTMKQICKEVYENYPAYDLTERKDFIKTTVKELIS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer，50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

引用文獻

DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma Q Bai,Frontiers in immunology,2024
Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis Jian Cao,Molecular pharmaceutics,2020

產品評價

靶點詳情

功能：

Involved in chromatin organization.
基因功能參考文獻：
1. These findings define DEK as an important and multifunctional mediator of homologous recombination. PMID: 28317934
2. DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy. PMID: 28165452
3. DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex. PMID: 29175155
4. Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth. PMID: 29538372
5. Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage. PMID: 29109007
6. DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation PMID: 25128083
7. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
8. Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas. PMID: 25049225
9. data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector PMID: 24608431
10. DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest. PMID: 21943234
11. The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein. PMID: 20827285
12. DEK is a neuroblastoma tumor antigen. PMID: 17397536
13. Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes. PMID: 17524367
14. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. PMID: 19223548
顯示更多

收起更多
亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: mmu:110052

STRING: 10090.ENSMUSP00000021807

UniGene: Mm.131150