Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Prex1), partial

中文名稱：

小鼠Prex1重組蛋白
貨號：

CSB-YP727969MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Prex1重組蛋白
貨號：

CSB-EP727969MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Prex1重組蛋白
貨號：

CSB-EP727969MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Prex1重組蛋白
貨號：

CSB-BP727969MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Prex1重組蛋白
貨號：

CSB-MP727969MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Prex1
Uniprot No.：

Q69ZK0
別名：

Prex1; Kiaa1415; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; PtdIns(3,4,5)-dependent Rac exchanger 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
基因功能參考文獻(xiàn)：
1. These findings identify P-Rex1 as a novel player of pulmonary fibrosis. PMID: 27173636
2. A novel mechanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin. PMID: 26792863
3. Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades. PMID: 26887924
4. findings suggest a vital role of P-Rex1 signaling in CA1 LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs PMID: 26621702
5. regulates GPCR-driven Rac signalling and actin polarity in neutrophils PMID: 24659802
6. Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment. PMID: 25538043
7. We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts. PMID: 25075639
8. P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers. PMID: 24327733
9. In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice. PMID: 23343834
10. P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway. PMID: 22965143
11. Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans. PMID: 22109529
12. Demonstrate presence of P-Rex1 in platelets as well as its role in platelet secretion and aggregation induced by low-dose agonists for g-protein coupled receptors and by collagen. PMID: 22207728
13. Studies identify a novel RacGEF in adipocytes as P-Rex1 that, at physiological insulin concentrations, functions as an insulin-dependent regulator of the actin cytoskeleton that contributes to GLUT4 trafficking to the plasma membrane. PMID: 22002247
14. Either P-Rex1 or Vav1 alone can produce sufficient active Rac for G protein-coupled receptor-dependent cell responses but under normal circumstances both contribute, presumably to ensure robust cell responses of primary neutrophils. PMID: 21178006
15. P-Rex1 is an important regulator of neutrophil function by mediating a subset of Rac-dependent neutrophil responses. PMID: 16243035
16. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. PMID: 16243036
17. P-Rex1 is one of the major GEFs in macrophage regulating Rac1 activation and chemotaxis. PMID: 18502673
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亞細(xì)胞定位：

Cytoplasm, cytosol. Cell membrane.
數(shù)據(jù)庫鏈接：

KEGG: mmu:277360

STRING: 10090.ENSMUSP00000037180

UniGene: Mm.34420