Recombinant Mouse Oncomodulin (Ocm)

中文名稱：

小鼠Ocm重組蛋白
品名簡稱：

Recombinant Mouse Ocm protein
貨號：

CSB-YP016264MO
說明書：

MSDS Datasheet
規(guī)格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Ocm
Uniprot No.：

P51879
別名：

Ocm; Oncomodulin; OM; Parvalbumin beta
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

Yeast
分子量：

14.1kDa
表達區(qū)域：

2-109aa
氨基酸序列

SITDILSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQLKDIFQFIDNDQSGYLDEDELKYFLQRFQSDARELTESETKSLMDAADNDGDGKIGADEFQEMVHS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產(chǎn)品描述：

In the production of recombinant Mouse Ocm protein, the gene for Ocm (Yeast) was cloned into a vector and expressed as Ocm protein in Yeast. The plasmids with the copy of Ocm, or the expression vector, were often used to enhance gene expression. Every step of production was undergone with a strict QC system. N-terminal 6xHis tag was used in the process. The purity is 90% determined by SDS-PAGE.
Oncomodulin (OCM) is a small EF-hand Ca2+-binding protein (CaBP) of approximately 12 kDa belonging to the parvalbumin family. Initially, OCM was considered oncogenic due to lack of evidence of any expression in normal post-embryonic tissue. However, decades after its initial discovery, OCM was identified as a major protein in sensory cells of the guinea pig cochlea. There are only a limited number of studies on the function of OCM largely due to its very restricted temporal and spatial expression patterns. Also, only a few OCM studies have addressed: intracellular concentration, affinity for metal ions, mobility, and Ca2+-sensing capacity. Existing findings show that OCM is evolutionarily distinguished from the majority of lower vertebrate β-parvalbumins. OCM may have an ambiguous function that depends upon the cell type in which it is expressed, and this ambiguity further distinguishes it from other EF-hand CaBPs. In sensory cells, recent studies suggest that OCM plays an essential role in maintaining auditory function, most likely affecting OHC motility mechanisms. In immune cells, OCM may be secreted in response to inflammatory signals and facilitates axon regeneration.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
基因功能參考文獻：
1. These data suggest that Ocm may have distinct functional roles in cochlear and vestibular hair cells. PMID: 20653034
2. absence of parvalbumin has no major effect on the GABA-synthesizing system in diencephalon presynaptic terminals; however, a likely homeostatic mechanism is induced resulting in the upregulation of oncomodulin in selected axons and neuronal perikarya PMID: 19874871
蛋白家族：

Parvalbumin family
組織特異性：

Found in tumor tissues and not detected in normal tissues.
數(shù)據(jù)庫鏈接：

KEGG: mmu:18261

STRING: 10090.ENSMUSP00000031622

UniGene: Mm.270533