Recombinant Mouse Nuclear receptor subfamily 2 group C member 2 (Nr2c2)
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中文名稱：小鼠Nr2c2重組蛋白
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貨號：CSB-EP016052MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：Nr2c2
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Uniprot No.：
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別名：Nr2c2; Mtr2r1; Tak1; Tr4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4
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種屬：Mus musculus (Mouse)
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蛋白長度：Full length protein
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表達區域：1-596
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氨基酸序列MTSPSPRIQI ISTDSAVASP QRIQIVTDQQ TGQKIQIVTA VDASGSSKQQ FILTSPDGAG TGKVILASPE TSSAKQLIFT TSDNLVPGRI QIVTDSASVE RLLGKADVQR PQVVEYCVVC GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSSQDCI INKHHRNRCQ FCRLKKCLEM GMKMESVQSE RKPFDVQREK PSNCAASTEK IYIRKDLRSP LIATPTFVAD KDGARQTGLL DPGMLVNIQQ PLIREDGTVL LAADSKAETS QGALGTLANV VTSLANLSES LNNGDASEMQ PEDQSASEIT RAFDTLAKAL NTTDSASPPS LADGIDASGG GSIHVISRDQ STPIIEVEGP LLSDTHVTFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFQAL GQDCNTSLVR ACWNELFTLG LAQCAQVMSL STILAAIVNH LQNSIQEDKL SGDRIKQVME HIWKLQEFCN SMAKLDIDGY EYAYLKAIVL FSPDHPGLTG TSQIEKFQEK AQMELQDYVQ KTYSEDTYRL ARILVRLPAL RLMSSNITEE LFFTGLIGNV SIDSIIPYIL KMETAEYNGQ ITGASL
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior.
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基因功能參考文獻：
- TNFalpha-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. PMID: 28842570
- The results suggest that an intron-free Renilla luciferase reporter may provide a satisfactory internal control for TR4 at certain dose range. Findings advocate caution on the use of Renilla luciferase as an internal control in TR4-directed studies to avoid misleading data interpretation. PMID: 28210900
- We conclude that TR4 is required for the normal differentiation and proliferation of erythroid cells, in addition to its previously characterized roles in embryonic and fetal globin gene repression PMID: 29018082
- CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions. PMID: 26985063
- SIRT7 inhibits TR4 degradation by deacetylation of DDB1. PMID: 28623141
- this study shows that TAK1 negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 activities PMID: 27671672
- TR4 binds GR to play an important role in glucocorticoid-directed corticotroph tumor POMC regulation in addition to modulating glucocorticoid actions on other GR targets. PMID: 27253665
- The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling. PMID: 27601471
- this study shows that increased activity of TAK1 contributes to diabetic nephropathy PMID: 27268284
- miR-133a regulates TR4 expression in ox-LDL-induced mouse RAW 264.7 macrophages PMID: 27109382
- TAK1 participates in intestinal integrity through separately modulating bacteria-derived reactive oxygen species and receptor-interacting protein kinase 3-dependent Paneth cell loss. PMID: 27077812
- We confirmed that PGC-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 binding and TAK1 activation. PMID: 26748475
- Hepatocyte TRAF3 promotes liver steatosis and insulin resistance through targeting TAK1-dependent signaling. PMID: 26882989
- Bacterial polysaccharide-responsive miR-150 and miR-143 RIPK2 and TAK1 to suppress NOD2-induced immunomodulators. PMID: 26391398
- TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene PMID: 25240193
- TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. PMID: 24583925
- These data provide new insights into our understanding of globin gene regulation and raise the interesting possibility that the PGC-1 coactivators can interact with TR4 to elicit differential stage-specific effects on globin gene transcription. PMID: 24662048
- TR4 transcriptionally activates proopiomelanocortin through binding of a direct repeat 1 response element in the promoter, and that this is enhanced by MAPK-mediated TR4 phosphorylation. PMID: 23653479
- The very profound pain and itch processing defects after TR4 deletion reflects loss of functionally distinct, and possibly independent, excitatory interneuronal circuits in the dorsal horn. PMID: 23622066
- Data from TR4 knockout mice suggest that TR4 has function in maintaining normal osteoblast activity during bone development and remodeling; TR4 may bind directly to promoter region of osteocalcin gene and induce osteocalcin expression. PMID: 22676849
- TR4 regulated the GADD45A expression through TR4 response elements located in intron 3 of the GADD45A gene. PMID: 22396141
- investigation of role of TR4 in penile physiology/sexual behavior using knockout mice: TR4-/- males exhibit severe reproductive malfunctions, abnormal sexual behavior, and loss of erectile function. TR4 binds/activates nNOS promoter/response element. PMID: 21995792
- Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair PMID: 21918225
- TR4 plays vital roles in mitochondrial function. PMID: 21622535
- microRNA-mediated silencing of TR4 in 3T3-L1 adipocytes drastically reduced basal FATP1 5' promoter activity and FATP1 expression with reduced lipid accumulation. PMID: 21843524
- A novel role of TR4 in mediating the interplay between oxidative stress defense and aging. PMID: 21521714
- TR4 transactivation is inhibited via phosphorylation by metformin-induced AMP-activated protein kinase (AMPK) at the amino acid serine 351, which results in the suppression of SCD1 gene expression. PMID: 21478464
- TAK1 plays a critical role in the regulation of energy and lipid homeostasis and may provide a new therapeutic target in the management of obesity, diabetes, and liver steatosis. PMID: 20864514
- Data show that gamma-linoleic acid positively modulates TR4 activity to promote the expression of downstream genes apolipoprotein E (ApoE) and phosphoenolpyruvate carboxykinase. PMID: 19800043
- TR4 can also regulate apolipoprotein E, C-I, and C-II gene expression via the TR4 response element within the hepatic control region PMID: 12954636
- TR4 plays a critical role in the late meiotic prophase and subsequent division in spermatogenesis PMID: 15199144
- plays important roles in growth, embryonic and early postnatal pup survival, female reproductive function, and maternal behavior PMID: 15477591
- TR4 is required for normal cerebellar development PMID: 15767677
- TR4 is required for proper myelination in the CNS and is particularly important for oligodendrocyte differentiation and maturation in the forebrain regions. PMID: 17227886
- These results demonstrate that TR4 might function as an apoptosis modulator through induction of Bcl-2 gene expression. PMID: 17655826
- Results showed TR4 might play essential roles in normal folliculogenesis by influencing LHR signals. PMID: 18174360
- Various TR4 knockout mouse models suggest that TR4 is required for normal cerebellar development and failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior. PMID: 18418664
- Reduced cluster of differentiation (CD)36 expression was found with reduced foam cell formation in TR4(-/-) mice. PMID: 19666541
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亞細胞定位：Nucleus.
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蛋白家族：Nuclear hormone receptor family, NR2 subfamily
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組織特異性：Expressed, during embryogenesis, in perichondrium, developing glomeruli structures and tubules of kidney, as well as in intestiinal villi. Also expressed in lung and hair follicles.
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