Recombinant Mouse Caveolae-associated protein 4 (Cavin4)

中文名稱：

Recombinant Mouse Caveolae-associated protein 4(Cavin4)
貨號：

CSB-YP015239MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Caveolae-associated protein 4(Cavin4)
貨號：

CSB-EP015239MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Caveolae-associated protein 4(Cavin4)
貨號：

CSB-EP015239MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Caveolae-associated protein 4(Cavin4)
貨號：

CSB-BP015239MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Caveolae-associated protein 4(Cavin4)
貨號：

CSB-MP015239MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cavin4
Uniprot No.：

A2AMM0
別名：

Cavin4; MurcCaveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-362
氨基酸序列

MEHNGSASNA GKIHQNRLSS VTEDEDQDAA LTIVTVLDRV ASVVDSVQAS QKRIEERHRE MGNAIKSVQI DLLKLSQSHS NTGYVVNKLF EKTRKVSAHI KDVKARVEKQ QVRVTKVETK QEEIMKKNKF RVVIFQEDIP CPASLSVVKD RSLPENQEEA EEVFDPPIEL SSDEEYYVEE SRSARLRKSG KEHIDHIKKA FSRENMQKTR QTLDKKVSGI RTRIVTPERR ERLRQSGERL RQSGERLRQS GERFKKSISS AAPSKEAFKI RSLRKAKDPK AEGQEVDRGM GVDIISGSLA LGPIHEFHSD EFSETEKEVT KGGYSPQEGG DPPTPEPLKV TFKPQVRVED DESLLLELKQ SS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
基因功能參考文獻(xiàn)：
1. MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling. PMID: 27546070
2. The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA) progression at the early stage via the activation of JNK and MMP-9. MURC/Cavin-4 is a potential therapeutic target against AAA progression. PMID: 28433630
3. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors. PMID: 24567387
4. MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias. PMID: 18332105
5. findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation PMID: 18508909
6. Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein. PMID: 19546242
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亞細(xì)胞定位：

Cytoplasm, myofibril, sarcomere. Cytoplasm. Cytoplasm, cytosol. Membrane, caveola. Cell membrane, sarcolemma. Cell membrane.
蛋白家族：

CAVIN family
組織特異性：

Abundantly expressed in cardiac and skeletal muscle (at protein level). Weaker expression in aorta and lung. In heart, expressed in cardiomyocytes and vascular smooth muscle cells but not in other surrounding cells including vascular endothelial cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:68016

STRING: 10090.ENSMUSP00000030033

UniGene: Mm.133444