Recombinant Mouse Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (Malt1), partial

中文名稱：

小鼠Malt1重組蛋白
貨號：

CSB-YP648780MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Malt1重組蛋白
貨號：

CSB-EP648780MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Malt1重組蛋白
貨號：

CSB-EP648780MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Malt1重組蛋白
貨號：

CSB-BP648780MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Malt1重組蛋白
貨號：

CSB-MP648780MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Malt1
Uniprot No.：

Q2TBA3
別名：

Malt1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; EC 3.4.22.-; Paracaspase
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
基因功能參考文獻(xiàn)：
1. this study shows that Malt1 protease activity plays an important role in the activation of innate immune cells via FcgammaR, and the development of FcgammaR-mediated autoimmune diseases PMID: 29414650
2. the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection. PMID: 29367251
3. MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions. PMID: 26405015
4. MALT1 function is required in B cells for germinal center formation. PMID: 28031341
5. Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE) PMID: 26386283
6. Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review) PMID: 26787500
7. TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation. PMID: 27068814
8. MALT1-dependent NF-kappaB activation is crucial for the development of EGFR-associated solid-tumor progression PMID: 25982276
9. By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB pathway. PMID: 26525107
10. Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo. PMID: 25965667
11. data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing platelet signals to the NF-kappaB pathway. PMID: 25748427
12. Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. PMID: 25319413
13. These results reveal distinct threshold and modulatory functions of Malt1 that differentially control lymphocyte differentiation and activation pathways. PMID: 25456129
14. Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex. PMID: 25202022
15. Upon recognition of antigen by the T cell antigen receptor (TCR), roquin and regnase-1 proteins were cleaved by the paracaspase MALT1. PMID: 25282160
16. TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement. PMID: 24825920
17. MALT1-knockout mice do not develop any clinical symptoms of experimental autoimmune encephalomyelitis; MALT1-deficient effector T cells are unable to induce demyelinating inflammation in the central nervous system. PMID: 23401595
18. MALT1 is a central, cell-intrinsic factor that determines the encephalitogenic potential of inflammatory Th17 cells in vivo. PMID: 23114599
19. work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human B-cell lymphomas PMID: 22689981
20. Authors provide biochemical and structural evidence that MALT1 activation is dependent on its dimerization and show that mutations at the dimer interface abrogate activity in cells. PMID: 22366302
21. findings demonstrate that primary T and B lymphocytes from paracaspase (MALT1)-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation PMID: 14576442
22. Malt1 is an essential positive mediator of IgE receptor Fc epsilon RI-dependent mast cell activation that selectively uncouples NF-kappa B-induced proinflammatory cytokine production from degranulation and leukotriene synthesis. PMID: 16432253
23. Data show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade. PMID: 16831874
24. Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production. PMID: 17095601
25. both Bcl10 and Malt1 are essential for TCR signaling in thymocytes as a genetic disruption of either molecule blocks TCR-induced NF-kappaB activation in these cells PMID: 17202357
26. Bcl-10 and MALT1 differentially regulated B cell receptor-induced activation of RelA and c-Rel. PMID: 17660823
27. Proliferative defects of CD4-positive T cells from caspase-like protein Malt1-deficient mice are primarily due to failure to activate NF-kappa B in response to T cell receptor ligation, whereas NF-KB activation in CD8+ T cells is independent of Malt1. PMID: 18941215
28. a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction. PMID: 19917778
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亞細(xì)胞定位：

Cytoplasm, perinuclear region. Nucleus.
蛋白家族：

Peptidase C14B family
數(shù)據(jù)庫鏈接：

KEGG: mmu:240354

STRING: 10090.ENSMUSP00000048376

UniGene: Mm.132613