Recombinant Mouse Mimecan (Ogn)

^{In
Stock}

中文名稱：

Recombinant Mouse Mimecan (Ogn)
品名簡稱：

Recombinant Mouse Ogn protein
貨號：

CSB-EP733811MO
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Ogn
Uniprot No.：

Q62000
別名：

Osteoglycin
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

38.7 kDa
表達區(qū)域：

20-298aa
氨基酸序列

APQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
基因功能參考文獻：
1. NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin. PMID: 29262349
2. These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells. PMID: 29161332
3. elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1). PMID: 28383550
4. OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration. PMID: 28069703
5. The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4. PMID: 27878326
6. mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus. PMID: 26870797
7. lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice PMID: 25463067
8. The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice. PMID: 22672618
9. Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues. PMID: 22351757
10. The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis. PMID: 22042093
11. even though there are 3-5 glucocorticoid response elements in the mimecan promoter, glucocorticoid may regulate mimecan transcription indirectly through the synthesis of intermediate proteins PMID: 21938403
12. Mimecan in pituitary corticotroph cells may regulate adrenocorticotrophic hormone secretion and the hypothalamo-pituitary-adrenal axis PMID: 21664248
13. High expression of osteoglycin decreases the gelatinase activity of hepatocarcinoma Hca-F cells cultured with extract of lymph node. PMID: 20027687
14. processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils PMID: 15292192
15. Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds PMID: 18243607
16. In summary, high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes. PMID: 18401533
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:18295

STRING: 10090.ENSMUSP00000021822

UniGene: Mm.4258