Recombinant Mouse Lysine-specific demethylase 5C (Kdm5c), partial

中文名稱：

小鼠Kdm5c重組蛋白
貨號：

CSB-YP012143MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Kdm5c重組蛋白
貨號：

CSB-EP012143MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Kdm5c重組蛋白
貨號：

CSB-EP012143MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Kdm5c重組蛋白
貨號：

CSB-BP012143MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Kdm5c重組蛋白
貨號：

CSB-MP012143MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Kdm5c
Uniprot No.：

P41230
別名：

Kdm5c; Jarid1c; Kiaa0234; Smcx; Xe169Lysine-specific demethylase 5C; EC 1.14.11.-; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
基因功能參考文獻：
1. Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons. PMID: 28978483
2. The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence. PMID: 27498878
3. Neurite growth in Neuro2a cells was suppressed by the KDM5C mutations associated with intellectual disability in patients. Ntng2 was downregulated in cells with KDM5C mutations, concordant with the lower levels of H3K4 methylation at its promoter. PMID: 27421841
4. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs. PMID: 26551685
5. The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes. PMID: 25255718
6. Kdm5c protein restricts transcriptional output at promoters, whereas Kdm5c binding to enhancers stimulates their activity. PMID: 23545502
7. sex-specific expression of Jarid1c may contribute to sex differences in brain function PMID: 18596936
8. allelic expression and RNA/DNA FISH indicate that transgenic Jarid1c escapes X inactivation. PMID: 18971342
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亞細胞定位：

Nucleus.
蛋白家族：

JARID1 histone demethylase family
數據庫鏈接：

KEGG: mmu:20591

STRING: 10090.ENSMUSP00000108207

UniGene: Mm.142655