Recombinant Mouse Lysine-specific demethylase 2B (Kdm2b), partial

中文名稱：

小鼠Kdm2b重組蛋白
貨號：

CSB-YP757551MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Kdm2b重組蛋白
貨號：

CSB-EP757551MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Kdm2b重組蛋白
貨號：

CSB-EP757551MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Kdm2b重組蛋白
貨號：

CSB-BP757551MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Kdm2b重組蛋白
貨號：

CSB-MP757551MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Kdm2b
Uniprot No.：

Q6P1G2
別名：

Kdm2b; Fbl10; Fbxl10; Jhdm1b; Kiaa3014Lysine-specific demethylase 2B; EC 1.14.11.27; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; [Histone-H3]-lysine-36 demethylase 1B
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
基因功能參考文獻：
1. tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively PMID: 29166607
2. Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype. PMID: 27646113
3. These results have not only identified an important epigenetic factor for iHep generation, but also brought new insight into the molecular nature of hepatogenesis and future biomedical applications for liver diseases. PMID: 27103435
4. roles in long-term sustainable spermatogenesis via regulating cell cycle PMID: 26984996
5. Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation. PMID: 25872778
6. FBXL10 protects Polycomb-occupied promoters against ectopic de novo methylation. PMID: 25848754
7. Genetic ablation in embryonic stem cells reveal that deletion of PRC1 has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1/PRC1 variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development. PMID: 24856970
8. Fbxl10 has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells. PMID: 23395003
9. KDM2B silencing abrogated tumorigenicity of PDAC cell lines exhibiting loss of epithelial differentiation, whereas KDM2B overexpression cooperated with KrasG12D to promote PDAC formation in mouse models. PMID: 23321669
10. a regulatory role of Fbxl10 in cell morphology, chemokine expression, and the metabolic control of fibroblasts. PMID: 22825849
11. The KDM2B-let-7-EZH2 pathway contributes to the proliferation of immortal Ink4a/Arf null fibroblasts suggesting the histone-modifying enzyme functions more broadly in the regulation of cellular proliferation. PMID: 21757686
12. Kdm2b/Jhdm1b functions as an oncogene and plays a critical role in leukemia development and maintenance. PMID: 21310926
13. Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice. PMID: 21220025
14. Data show that Ndy1 protects from hydrogen peroxide-induced apoptosis and G(2)/M arrest and inhibits ROS-mediated signaling and DNA damage, while knockdown of Ndy1 has the opposite effects. PMID: 18838535
15. Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor PMID: 17296600
16. Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b). PMID: 18836456
17. studies show that, in addition to inhibiting replicative senescence, Ndy1 inhibits Ras oncogene-induced senescence via a similar molecular mechanism PMID: 19202064
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亞細胞定位：

Nucleus, nucleolus. Nucleus. Chromosome.
蛋白家族：

JHDM1 histone demethylase family
數據庫鏈接：

KEGG: mmu:30841

STRING: 10090.ENSMUSP00000038229

UniGene: Mm.86406