Recombinant Mouse Leucine zipper putative tumor suppressor 1 (Lzts1)

中文名稱：

小鼠Lzts1重組蛋白
貨號：

CSB-YP013291MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lzts1重組蛋白
貨號：

CSB-EP013291MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lzts1重組蛋白
貨號：

CSB-BP013291MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lzts1重組蛋白
貨號：

CSB-MP013291MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lzts1
Uniprot No.：

P60853
別名：

Lzts1; Fez1Leucine zipper putative tumor suppressor 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-599
氨基酸序列

GSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GRGKSSSKMG KSEDFFYIKV SQKARGSHRP DYTALSSGDI GGQTGVDFDP ATPPKLMPFS NQLEMSSDKG AVRPTAFKPV LPRSGAILHS SPESTSHQLH PMPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTTSS YQLDPLVTPV GPTSRFGGSA HNITQGIILQ DSNMMSLKAL SFSDGGSKLA HPGKADKGAS CVRSPLSTDE CTIQELEQKL LQRETALQKL QRSFDEKEFA SGQTFEERPR RTRDELECLE PKSKLKPPSQ KSQRTQQVLQ LQVLQLQQEK RQLRQELESL MKEQDLLETK LRSYEREKTN FAPALEETQW EVCQKSGEIS LLKQQLKESQ LEVNTKASEI LSLKAQLKDT RGKLDGMELK TQDLESALRT KGLELEVCEN ELQRKKNEAE LLREKVNLLE QELMELRAQA ALHPAPLGPP GVGLTFSEDI PALQRELDRL RAELKEERQG HDQMSSGFQH ERLVWKEEKE KVIQYQRQLQ QSYLAMYQRN QRLEKALQQL ARGDGPGEPF EIDLEGADIP YEDIIATEI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor.
基因功能參考文獻：
1. The results of this study provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70. PMID: 26490870
2. Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons. PMID: 22419569
3. Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice. PMID: 17349584
4. Partial or complete loss of Lzts1 downregulates Cdc25C and inhibits Cdk1 activity during mitosis, leading to premature transition from metaphase to anaphase. PMID: 17419986
5. Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 a target for gene therapy. PMID: 18192690
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亞細胞定位：

Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
蛋白家族：

LZTS family
數據庫鏈接：

KEGG: mmu:211134

STRING: 10090.ENSMUSP00000039397

UniGene: Mm.409446