Recombinant Mouse Leucine-rich PPR motif-containing protein, mitochondrial (Lrpprc), partial

中文名稱：

小鼠Lrpprc重組蛋白
貨號：

CSB-YP761321MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lrpprc重組蛋白
貨號：

CSB-EP761321MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lrpprc重組蛋白
貨號：

CSB-EP761321MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lrpprc重組蛋白
貨號：

CSB-BP761321MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lrpprc重組蛋白
貨號：

CSB-MP761321MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lrpprc
Uniprot No.：

Q6PB66
別名：

Lrpprc; Lrp130; Leucine-rich PPR motif-containing protein; mitochondrial; 130 kDa leucine-rich protein; LRP 130; mLRP130
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA.
基因功能參考文獻：
1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. PMID: 29146908
2. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins. PMID: 28473468
3. both LRPPRC and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC-SLIRP complex. PMID: 26247782
4. Ectopic expression of LRPPRC in the mouse liver completely interdicted non-alcoholic fatty liver disease, including inflammation. PMID: 25933096
5. LRPPRC deficiency in Leigh syndrome causes an ATP synthase deficiency. PMID: 24399447
6. LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression. PMID: 23599432
7. Heart-specific Lrpprc disruption causes mitochondrial cardiomyopathy with drastic reduction in steady-state mitochondrial mRNA levels. LRPPRC forms an RNA-dependent protein complex needed to maintain a mitochondrial pool of non-translated mRNAs. PMID: 22045337
8. These data strongly suggest that LRPPRC is involved in the maturation of cytochrome c oxidase (COX), and is involved in stabilizing of mitochondrial mRNAs encoding COX transcripts. PMID: 21880015
9. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. PMID: 21971050
10. Our results demonstrate that LIF signaling via the gp130/JAK/STAT3 pathway is required for the initiation of the astrogliosis-like reaction of retinal Muller cells after optic nerve injury. PMID: 20091786
11. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~74%. PMID: 19372376
12. LRP130 may function in stabilizing minisatellite DNA sequences. PMID: 12071956
13. associates with mRNA/mRNP complexes at the outside of nuclear/endoplasmic reticulum, and plays a role in control of mRNA metabolisms PMID: 15081402
14. These data link LRP130 and PGC-1alpha to defective hepatic energy homeostasis in Leigh syndrome French Canadian variant , and reveal a novel regulatory mechanism of glucose homeostasis. PMID: 17050673
15. brown fat cell development common to both PGC-1 coactivators is governed by LRP130 PMID: 18728005
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亞細胞定位：

Mitochondrion. Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
組織特異性：

Strongly expressed in heart, liver and kidney. Weakly expressed in brain, skeletal muscle and testes.
數據庫鏈接：

KEGG: mmu:72416

STRING: 10090.ENSMUSP00000107927

UniGene: Mm.217027