Recombinant Mouse LanC-like protein 1 (Lancl1)

中文名稱：

小鼠Lancl1重組蛋白
貨號：

CSB-YP012742MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lancl1重組蛋白
貨號：

CSB-EP012742MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lancl1重組蛋白
貨號：

CSB-EP012742MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lancl1重組蛋白
貨號：

CSB-BP012742MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lancl1重組蛋白
貨號：

CSB-MP012742MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lancl1
Uniprot No.：

O89112
別名：

Lancl1; Gpr69aGlutathione S-transferase LANCL1; EC 2.5.1.18; 40 kDa erythrocyte membrane protein; p40; LanC-like protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-399
氨基酸序列

AQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG LKSADPRDGT GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKQSLNCLS RRSITFLCGD AGPLAVAAVL YHKMNSEKQA EECITRLIHL NKIDPHVPNE MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ QICENILTSG ENLSRKRNLA AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVNQGKL HSLVKPSVDF VCRLKFPSGN YPPCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEERYLC DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DLKYLYRACK FAEWCLDYGE HGCRTADTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione.
基因功能參考文獻：
1. Very similar concentrations of lanthionine ketimine (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis. PMID: 28106097
2. Loss of LanCL1 causes progressive oxidative damage and neuronal death. LanCL1 transgene protects neurons from oxidative stress. PMID: 25158856
3. LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse. PMID: 14514412
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein.
蛋白家族：

LanC-like protein family
組織特異性：

Detected in spinal cord (at protein level). Ubiquitous. Strongly expressed in brain, testis, alveolar macrophages and epithelial cells of the lung, kidney and intestine. Expression in brain increases during the first postnatal month and remaining high in
數據庫鏈接：

KEGG: mmu:14768

STRING: 10090.ENSMUSP00000027149

UniGene: Mm.20522