Recombinant Mouse Homeobox protein engrailed-2 (En2)

中文名稱：

小鼠En2重組蛋白
貨號：

CSB-YP007660MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠En2重組蛋白
貨號：

CSB-EP007660MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠En2重組蛋白
貨號：

CSB-EP007660MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠En2重組蛋白
貨號：

CSB-BP007660MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠En2重組蛋白
貨號：

CSB-MP007660MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

En2
Uniprot No.：

P09066
別名：

En2; En-2; Homeobox protein engrailed-2; Homeobox protein en-2; Mo-En-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-324
氨基酸序列

MEEKDSKPSE TAAEAQRQPE PSSGGGSGGG SSPSDSDTGR RRALMLPEVL QAPGNHQHPH RITNFFIDNI LRPEFGRRKD AGTCCAGAGG ARGGEGGAGT TEGGGGGAGG AEQLLGARES RPNPACAPSA GGTLSAAAGD PAVDGEGGSK TLSLHGGAKK PGDPGGSLDG VLKARGLGGG DLSVSSDSDS SQASATLGAQ PMLWPAWVYC TRYSDRPSSG PRSRKPKKKN PNKEDKRPRT AFTAEQLQRL KAEFQTNRYL TEQRRQSLAQ ELSLNESQIK IWFQNKRAKI KKATGNKNTL AVHLMAQGLY NHSTTAKEGK SDSE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. This study demonstrated that Ketogenic diet exposure during the juvenile period increases social behaviors and forebrain neural activation in adult Engrailed 2 null mice. PMID: 27080080
2. En2 deletion reduces monoamine innervation of target forebrain structures, affecting forebrain structural growth, postnatal neurogenesis and related behavior. PMID: 26220976
3. confirm the early neurotransmitter deficit with a late compensatory recovery in En2 KO-mice further suggesting that this experimental animal may be considered a good predictive model for the human disease PMID: 26002543
4. En2-/- hippocampus, neurofibromin-dependent pathways converging on SynI phosphorylation might underlie hippocampal-dependent learning deficits observed in En2-/- mice. PMID: 25463523
5. This study demonistrated that engrailed 2 knock-out mice show impaired spatial learning with hippocampal dysreulation. PMID: 25274808
6. EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene. PMID: 24520327
7. This study showed that the Engrailed proteins are present in postnatal GABAergic neurons of the mouse hippocampus and cerebral cortex, and adult En2(-/-) mice show reduced expression of GABAergic marker mRNAs in these areas. PMID: 23360806
8. En1 is the predominant functional En paralog in maturing 5-HT neurons, although a small contribution from En2 was reproducibly detected PMID: 22674259
9. The data of this study suggested that in En2-/- mice nigrostriatal degeneration in the substantia nigra is functionally PMID: 21104462
10. En-2 is expressed in mandibular arch myoblasts of the mouse. The activity of the En-2 enhancer is maintained in several functionally related muscles that arise from the first arch PMID: 11804784
11. Physiological downregulation of En-2 around the day of birth in normal Purkinje cells (PCs) is critical for the timing of distinct steps of PC differentiation. PMID: 15024754
12. En2(-/-) mice display behavioral and neurochemical changes, in addition to genetic and neuropathological changes, relevant to autism spectrum disorder PMID: 16935268
13. The En2 knock-out mouse harbors cerebellar abnormalities that are similar to those found in autistic individuals and has a distinct anterior shift in the position of the amygdala in the cerebral cortex. PMID: 17055592
14. Genetic subdivision of the tectum and cerebellum into functionally related regions is based on differential sensitivity to En2. PMID: 17537797
15. En2(-/-) mice displayed an increased susceptibility to kainic acid -induced seizures. PMID: 19186208
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亞細胞定位：

Nucleus.
蛋白家族：

Engrailed homeobox family
組織特異性：

Cerebellar granule cells.
數據庫鏈接：

KEGG: mmu:13799

STRING: 10090.ENSMUSP00000036761

UniGene: Mm.4298