Recombinant Mouse Guanylin (Guca2a)

中文名稱：

小鼠Guca2a重組蛋白
貨號：

CSB-YP010047MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Guca2a重組蛋白
貨號：

CSB-EP010047MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Guca2a重組蛋白
貨號：

CSB-EP010047MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Guca2a重組蛋白
貨號：

CSB-BP010047MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Guca2a重組蛋白
貨號：

CSB-MP010047MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Guca2a
Uniprot No.：

P33680
別名：

Guca2a; Guca2; Guanylin; Guanylate cyclase activator 2A
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
表達區域：

102-116
氨基酸序列

PNTCEICAY AACTGC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
基因功能參考文獻：
1. Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. PMID: 29289697
2. guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage PMID: 27246004
3. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes PMID: 14675035
4. These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable enterotoxin (STa) in mouse proximal colon. PMID: 15026148
5. existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney PMID: 16105031
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亞細胞定位：

Secreted.
蛋白家族：

Guanylin family
組織特異性：

Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon.
數據庫鏈接：

KEGG: mmu:14915

STRING: 10090.ENSMUSP00000024015

UniGene: Mm.2614