Recombinant Mouse Epithelial splicing regulatory protein 1 (Esrp1)

中文名稱：

小鼠Esrp1重組蛋白
貨號：

CSB-YP007832MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Esrp1重組蛋白
貨號：

CSB-EP007832MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Esrp1重組蛋白
貨號：

CSB-EP007832MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Esrp1重組蛋白
貨號：

CSB-BP007832MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Esrp1重組蛋白
貨號：

CSB-MP007832MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Esrp1
Uniprot No.：

Q3US41
別名：

Epithelial splicing regulatory protein 1; Epithelial splicing regulatory protein 2; Esrp1; ESRP1_MOUSE; ESRP2; PP7059; RNA binding motif protein 35B; RNA-binding motif protein 35A; RNA-binding motif protein 35B; RNA-binding protein 35A; RNA-binding protein 35B
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-680
氨基酸序列

MTASPDYLVV LFGITAGATG AKLGSDEKEL ILLLWKVVDL ANKKVGQLHE VLVRPDQLEL TEDCKEETKI DAENLSSAPQ LDQALRQFNQ SVSNELNIGV GTSFCLCTDG QLHIRQILHP EASKKNVLLP ECFYSFFDLR KEFKKCCPGS PDIDKLDVAA MTESLNFEKS DSVSRYGASQ VEDMGNIILA MISEPYNHRF SDPERVNYKF ESGTCKMELI DDSTVVRARG LPWQSSDQDI ARFFKGLNIA KGGAALCLNA QGRRNGEALV RFVSEEHRDL ALQRHKHHMG TRYIEVYKAT GEDFLKIAGG TSNEVAQFLS KENQVIVRMR GLPFTATAEE VVAFFGQHCP ITGGKEGILF VTYPDGRPTG DAFVLFACEE YAQNALRKHK ELLGKRYIEL FRSTAAEVQQ VLNRFSSAPL IPLPTPPIIP VLPQQFVPPT NVRDCIRLRG LPYAATIEDI LDFLGEFSTD IRTHGVHMVL NHQGRPSGDA FIQMKSTDRA FMAAQKYHKK TMKDRYVEVF QCSAEEMNFV LMGGTLNRNG LSPPPCKLPC LSPPSYTFPA PTAVIPTEAA IYQPSLLLNP RALQPSTAYY PAGTQLFMNY TAYYPSPPGS PNSLGYFPTA ANLSSVPPQP GTVVRMQGLA YNTGVKEILN FFQGYQYATE DGLVHTNDQA RTLPKEWVCI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium.
基因功能參考文獻：
1. Study documented the expression of Esrp1 during gonadal development and in differentiating cells of the adult gonads: in mouse fetal gonads, Esrp1 mRNA was specifically detected in germ cells of either sex and absent from somatic gonadal cells. Esrp1 mRNA was present in a gonocyte-enriched cell fraction and in all germ cells examined in postnatal testis. PMID: 29324788
2. Findings reveal that Esrp1-regulated splicing in ureteric epithelial cells plays an important role in renal development. Defects in Esrp1 KO kidneys likely reflect reduced and/or absent ureteric branching, leading to decreased nephron induction secondary to incorrect Fgfr2 splicing and other splicing alterations PMID: 27404344
3. implicate mutations in Epithelial Splicing-Regulatory Protein 1 as a cause of SNHL and demonstrate the complex interplay between alternative splicing PMID: 29107558
4. ESRP1 thus acts as a physiological regulator of the finely-tuned balance between self-renewal and commitment to a restricted developmental fate. PMID: 24015231
5. Esrp1 could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo. PMID: 23233200
6. Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. PMID: 22673910
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亞細胞定位：

Nucleus.
蛋白家族：

ESRP family
組織特異性：

Epithelial cell-specific. Epithelial-specific expression in diverse tissues and organs with particularly notable levels of expression in skin and gastrointestinal epithelia.
數據庫鏈接：

KEGG: mmu:207920

STRING: 10090.ENSMUSP00000103947

UniGene: Mm.387719