Recombinant Mouse ETS domain-containing protein Elk-1 (Elk1)

中文名稱：

小鼠Elk1重組蛋白
貨號：

CSB-YP007603MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Elk1重組蛋白
貨號：

CSB-EP007603MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Elk1重組蛋白
貨號：

CSB-EP007603MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Elk1重組蛋白
貨號：

CSB-BP007603MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Elk1重組蛋白
貨號：

CSB-MP007603MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Elk1
Uniprot No.：

P41969
別名：

Elk1ETS domain-containing protein Elk-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-429
氨基酸序列

MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTSA IAMAPATVHA GPGDTATGKP GTPKGAGMTG QGGLARSSRN EYMRSGLYST FTIQSLQPQP QPPIPPRPAS VLPNTTPAGV PAPASGSRST SPNPLEACLE AEEAGLPLQV ILTPPEAPNQ KSEELSLDPS FGHPQPPEVK VEGPKEELEA ARAGGFSSEA VKAEPEVSAS EGLLARLPAI LTENTAQVCG LSTSTTEITQ PQKGRKPRDL ELPLSPSLLG GQGPERTPGS GTSSGLQAPG PALTPSLLPT HTLTPVLLTP SSLPPSIHFW STLSPIAPRS PAKLSFQFPS SGSAQVHIPS ISVDGLSTPV VLSPGPQKP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation.
基因功能參考文獻：
1. the effects of vitamin C inhibiting the apo(a) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells PMID: 28192139
2. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID: 26861876
3. A role for Elk-1 in the transcriptional regulation of DUSP5 PMID: 26691724
4. TNF-alpha modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1. PMID: 24121020
5. novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. PMID: 23893408
6. Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element. PMID: 22811558
7. increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection PMID: 22372926
8. Characterizes an orthologous rat short isoform derived from an in-frame downstream start codon. PMID: 11050086
9. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes PMID: 21846717
10. Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine. PMID: 21976515
11. we aimed to identify the critical promoter regions of SPG4 gene and effects of Elk1 on SPG4 gene expression PMID: 21395583
12. Results suggest a combined role for the transcription factors NF-kappaB and Elk-1 in the upregulation of AT(1)R in the CATH.a cell neuronal model. PMID: 20554912
13. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1. PMID: 20554967
14. The ability of Elk-1 to induce HO-1 promoter activity was independent of direct DNA binding, but rather occurred by interacting with the CCAAT/enhancer-binding protein-alpha (C/EBPalpha), which binds to DNA. PMID: 20348279
15. Elk1 synergizes with C/EBP beta in the Ras-stimulated transactivation of the c-fos serum response element. PMID: 11151091
16. H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin PMID: 15576363
17. Elk-1 regulates telokin expression PMID: 16260603
18. Data show that ERK1/2 regulates angiotensin II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. PMID: 16723511
19. We suggest that LTD leads to SRF/Elk-1-regulated gene expression of immediate early transcription factors, which could in turn promote a second broader wave of gene expression. PMID: 16903857
20. JNK1 and JNK2 differentially regulate TBP through Elk-1, controlling c-Jun expression and cell proliferation PMID: 17074809
21. Results describe the role of Elk-1 in tumorigenesis, and show that the ElK-1 antisense oligonucleotide suppresses the tumorigenicity of human hepatocellular carcinoma cells. PMID: 17950002
22. muscle differentiation is associated with a pattern of transcription factors that involves nuclear exclusion ELK1 and Forkhead box O and the increase in nuclear factor-kappaB DNA binding PMID: 17962350
23. enhanced neuron-specific phosphorylation of Elk-1 at Ser383 is involved in cerebral cerebral hypoxic preconditioning of mice PMID: 19225881
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亞細胞定位：

Nucleus.
蛋白家族：

ETS family
組織特異性：

Predominantly expressed in the brain, and to a lesser extent in the heart, liver and muscle.
數據庫鏈接：

KEGG: mmu:13712

STRING: 10090.ENSMUSP00000009550

UniGene: Mm.405823