Recombinant Mouse Death domain-containing protein CRADD (Cradd)

中文名稱：

Recombinant Mouse Death domain-containing protein CRADD(Cradd)
貨號：

CSB-YP005938MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Death domain-containing protein CRADD(Cradd)
貨號：

CSB-EP005938MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Death domain-containing protein CRADD(Cradd)
貨號：

CSB-EP005938MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Death domain-containing protein CRADD(Cradd)
貨號：

CSB-BP005938MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Death domain-containing protein CRADD(Cradd)
貨號：

CSB-MP005938MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cradd
Uniprot No.：

O88843
別名：

Cradd; RaiddDeath domain-containing protein CRADD; Caspase and RIP adapter with death domain; RIP-associated protein with a death domain
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-199
氨基酸序列

MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEIKAQTTG LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLEKAR EEVTAELPTG DWMAGIPSHI LSSSPSDQQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA NHPHNVHSQV VEAFVRWRQR FGKQATFLSL HKGLQAVEAD PSLLQHMLE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
基因功能參考文獻：
1. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists PMID: 24958727
2. Neuronal caspase-2-dependent execution of neurons requires recptor-interacting protein RAIDD, not p53-inducible protein with a death domain (PIDD). PMID: 22515271
3. Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes. PMID: 12558660
4. P53-induced protein with a death domain -induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor-interacting protein (RIP)-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD). PMID: 16183742
亞細胞定位：

Cytoplasm. Nucleus.
數據庫鏈接：

KEGG: mmu:12905

STRING: 10090.ENSMUSP00000050295

UniGene: Mm.473739