Recombinant Mouse Cytosolic carboxypeptidase 1 (Agtpbp1), partial

中文名稱：

Recombinant Mouse Cytosolic carboxypeptidase 1(Agtpbp1) ,partial
貨號：

CSB-YP731034MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cytosolic carboxypeptidase 1(Agtpbp1) ,partial
貨號：

CSB-EP731034MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cytosolic carboxypeptidase 1(Agtpbp1) ,partial
貨號：

CSB-EP731034MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cytosolic carboxypeptidase 1(Agtpbp1) ,partial
貨號：

CSB-BP731034MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cytosolic carboxypeptidase 1(Agtpbp1) ,partial
貨號：

CSB-MP731034MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Agtpbp1
Uniprot No.：

Q641K1
別名：

Agtpbp1; Ccp1; Nna1; Cytosolic carboxypeptidase 1; EC 3.4.17.-; ATP/GTP-binding protein 1; Nervous system nuclear protein induced by axotomy protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
基因功能參考文獻：
1. Lack of Cytosolic Carboxypeptidase 1 Leads to Subfertility due to the Reduced Number of Antral Follicles in pcd3J-/- Females. PMID: 26452267
2. Nna1 and CCP4 remove the C-terminal glutamate from substrates with two or more glutamates, whereas CCP6 requires four or more glutamates. CCP4 behaves as a promiscuous glutamase with little preference for chain length or neighboring amino acid composition PMID: 25416787
3. The lack of CCP1/Nna1 leads to decreases in cellular levels of amino acids, which leads to elevated autophagy as a protective response to cellular amino acid starvation. PMID: 20484972
4. The nna1 deficiency demonistrated that gliosis occurring during mitral cells and Purkinje cells death in the PCD mouse. PMID: 23047288
5. This study characterized the structure, expression and activity of wild type and mutated Nna1 in Purkinje cell degeneration (pcd) mice. PMID: 22835831
6. These data indicated that serotonergic function in the MOB is closely related to olfactory activity and that mitral cell loss induces serotonergic plastic responses. PMID: 22133893
7. Agtpbp1 plays an important role in spermatogenesis and is important for survival of germ cells at spermatocytes stage onward PMID: 21110128
8. Study analyzes Purkinje cell degeneration (pcd) mice that lack functional CCP1 and shows that microtubule hyperglutamylation is directly linked to neurodegeneration. PMID: 21074048
9. This study provided insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable. PMID: 20920790
10. This studies indicated that Nna1 loss of function results in altered bioenergetics and mitochondrial dysfunction. PMID: 20620870
11. identifed Nna1 as the gene mutated in the original Purkinje cell degeneration(pcd)and two additional pcd alleles (pcd2J and pcd3J) PMID: 11884758
12. loss of Nna1 in Purkinje cells leads directly to their degeneration and Nna1's carboxypeptidase domain is essential for survival of these neurons PMID: 16952463
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相關疾病：

Defects in Agtpbp1 are the cause of Purkinje cell degeneration (pcd). Pcd is a spontaneous mutation that causes adult-onset degeneration of cerebellar Purkinje neurons, retinal photoreceptors, olfactory bulb mitral neurons, and selected thalamic neurons, and has defective spermatogenesis. Defects in mitochondrial metabolic functions are also observed. The molecular causes of neurodegeneration are still unclear, but they are probably due to an accumulation of glutamylation, either tubulin hyperglutamylation or another hyperglutamylated target proteins. An increase of intranuclear localization of lysyl oxidase (Lox) propeptide, which interferes with NF-kappa-B Rela signaling and microtubule-associated protein regulation of microtubule stability is also observed, possibly leading to underdevelopment of Purkinje cell dendrites.
亞細胞定位：

Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion.
蛋白家族：

Peptidase M14 family
組織特異性：

Widely expressed. Highly expressed in the cerebellum and cortex of adult mouse brain. Expressed at similar levels in both the cerebellum and the cortex throughout all developmental stages. Also expressed in sciatic nerve transection, spinal motor neurons
數據庫鏈接：

KEGG: mmu:67269

STRING: 10090.ENSMUSP00000022040

UniGene: Mm.153008