Recombinant Mouse Cytochrome P450 11B2, mitochondrial (Cyp11b2)

中文名稱：

Recombinant Mouse Cytochrome P450 11B2, mitochondrial(Cyp11b2)
貨號(hào)：

CSB-YP006391MO
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cytochrome P450 11B2, mitochondrial(Cyp11b2)
貨號(hào)：

CSB-EP006391MO
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cytochrome P450 11B2, mitochondrial(Cyp11b2)
貨號(hào)：

CSB-EP006391MO-B
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cytochrome P450 11B2, mitochondrial(Cyp11b2)
貨號(hào)：

CSB-BP006391MO
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cytochrome P450 11B2, mitochondrial(Cyp11b2)
貨號(hào)：

CSB-MP006391MO
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cyp11b2
Uniprot No.：

P15539
別名：

Cyp11b2; Cyp11b-2Cytochrome P450 11B2; mitochondrial; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase; CYP11B2; EC 1.14.15.5; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450C11; Steroid 11-beta-hydroxylase; CYP11B2; EC 1.14.15.4; Steroid 18-hydroxylase
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

25-500
氨基酸序列

GTTATL APKTLQPFEA IPQYSRNKWL KMIQILREQG QENLHLEMHQ VFRELGPIFR HSVGKTQIVS VMLPEDAEKL HQVESMLPRR MHLEPWVAHR ELRGLRRGVF LLNGPEWRLN RLRLNRNVLS PKAVQKFVPM VDMVARDFLE TLKEKVLQNA RGSLTMDVQQ SLFNYTIEAS NFALFGERLG LLGHDLSPGS LKFIHALHSM FKSTSQLLFL PKSLTRWTST RVWKEHFDAW DVISEYANRC IWKVHQELRL GSSQTYSGIV AELISQGSLP LDAIKANSME LTAGSVDTTA IPLVMTLFEL ARNPDVQKAL RQESLAAEAS IAANPQKAMS DLPLLRAALK ETLRLYPVGG FLERILSSDL VLQNYHVPAG TLVLLYLYSM GRNPAVFPRP ERYMPQRWLE RKRSFQHLAF GFGVRQCLGR RLAEVEMMLL LHHILKTFQV ETLRQEDVQM AYRFVLMPSS SPVLTFRPVS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
基因功能參考文獻(xiàn)：
1. Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium PMID: 26324851
2. Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation. PMID: 26047574
3. Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1 PMID: 11932209
4. Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets. PMID: 18039983
亞細(xì)胞定位：

Mitochondrion inner membrane; Peripheral membrane protein.
蛋白家族：

Cytochrome P450 family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:13072

STRING: 10090.ENSMUSP00000131503

UniGene: Mm.377079