Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (Cmah)

中文名稱：

Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(Cmah)
貨號：

CSB-YP717212MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(Cmah)
貨號：

CSB-EP717212MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(Cmah)
貨號：

CSB-EP717212MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(Cmah)
貨號：

CSB-BP717212MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(Cmah)
貨號：

CSB-MP717212MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cmah
Uniprot No.：

Q61419
別名：

CmahCytidine monophosphate-N-acetylneuraminic acid hydroxylase; CMP-N-acetylneuraminic acid hydroxylase; EC 1.14.18.2; CMP-N-acetylneuraminate monooxygenase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

5-577
氨基酸序列

KQTAET LLTLSPAEVA NLKEGINFFR NKTTGKEYIL YKEKDHLKAC KNLCKHQGGL FMKDIEDLDG RSVKCTKHNW KLDVSTMKYI NPPGSFCQDE LVIEMDENNG LSLVELNPPN PWDSDPRSPE ELAFGEVQIT YLTHACMDLK LGDKRMVFDP WLIGPAFARG WWLLHEPPSD WLERLCKADL IYISHMHSDH LSYPTLKQLS QRRPDIPIYV GDTERPVFWN LDQSGVGLTN INVVPFGIWQ QVDKSLRFMI LMDGVHPEMD TCIIVEYKGH KILNTVDCTR PNGGRLPEKV ALMMSDFAGG ASGFPMTFSG GKFTEEWKAQ FIKAERRKLL NYKAQLVKDL QPRIYCPFAG YFVESHPSDK YIKETNTKND PNQLNNLIRK NSDVVTWTPR PGAVLDLGRM LKDPTDSKGI VEPPEGTKIY KDSWDFGPYL EILNSAVRDE IFCHSSWIKE YFTWAGFKNY NLVVRMIETD EDFSPFPGGY DYLVDFLDLS FPKERPSREH PYEEIHSRVD VIRYVVKNGL LWDDLYIGFQ TRLLRDPDIY HHLFWNHFQI KLPLTPPNWK SFLMHCD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.
基因功能參考文獻：
1. These findings have the potential to significantly advance our understanding of how this enigmatic tumor-associated antigen is produced in humans, and also suggest a possible mechanism of action of anti-tumor antibodies that recognize hypoxia markers, such as 14F7. PMID: 29196263
2. this study shows that Cmah(-/-) mice manifest a decreased survival in endotoxemia following bacterial lipopolysaccharide injection, and that macrophages from Cmah(-/-) mice secrete more inflammatory cytokines with LPS stimulation and show more phagocytic activity PMID: 28148732
3. Used CMP-Neu5Ac Hydroxylase null mouse models to study the modification/turnover of gene products that are altered in humans due to evolutionary loss of Neu5Gc. PMID: 26558285
4. The target miRNAs are closely associated with dysregulation of insulin/PI3K-AKT signaling, suggesting that the Cmah-null mice could be a useful model for studying diabetes. PMID: 25243123
5. Mice bearing a human-like deletion of the Cmah gene serve as an important model for the study of abnormal pathogenesis and/or metabolism caused by the evolutionary loss of Neu5Gc synthesis in humans. PMID: 25229777
6. In vitro T cell proliferation and activation is augmented in Cmah-deficient mice. PMID: 23709682
7. This study showed that mice bearing a human-like deletion of the Cmah gene exhibit fasting hyperglycemia and glucose intolerance following a high-fat diet. PMID: 21350118
8. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. PMID: 20668298
9. Cmah was inactivated and the in vivo consequences were studied. PMID: 17420276
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亞細胞定位：

Cytoplasm.; [Isoform 2]: Endoplasmic reticulum.
蛋白家族：

CMP-Neu5Ac hydroxylase family
組織特異性：

Expressed in all tissues tested, except in brain.
數據庫鏈接：

KEGG: mmu:12763

STRING: 10090.ENSMUSP00000061045

UniGene: Mm.8396