Recombinant Mouse Cullin-4B (Cul4b), partial
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中文名稱：Recombinant Mouse Cullin-4B(Cul4b) ,partial
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貨號：CSB-YP006222MO
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說明書：
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規格：
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來源：Yeast
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其他：
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中文名稱：Recombinant Mouse Cullin-4B(Cul4b) ,partial
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貨號：CSB-EP006222MO
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說明書：
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規格：
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來源：E.coli
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其他：
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中文名稱：Recombinant Mouse Cullin-4B(Cul4b) ,partial
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貨號：CSB-EP006222MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
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中文名稱：Recombinant Mouse Cullin-4B(Cul4b) ,partial
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貨號：CSB-BP006222MO
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說明書：
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規格：
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來源：Baculovirus
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Cul4b; mKIAA0695Cullin-4B; CUL-4B
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種屬：Mus musculus (Mouse)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes. Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis.
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基因功能參考文獻：
- A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions PMID: 28604389
- Adipocyte-specific Cul4b knockout (AKO) mice being fed a high-fat diet exhibited increased body fat accumulation that was mediated by increased adipogenesis. However, AKO mice showed improved metabolic phenotypes, including increased insulin sensitivity and glucose tolerance. Correspondingly, there was a decreased inflammatory response in adipose tissues of AKO mice. PMID: 27899484
- CUL4B as a key regulator of post-meiotic sperm morphogenesis PMID: 26832838
- CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis. PMID: 26846852
- results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice PMID: 25945838
- Ptgds is targeted and repressed by the CUL4B/PRC2 complex. PMID: 26025376
- FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. PMID: 25970626
- CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice. PMID: 25855927
- Data indicate a role of cullin family, CUL4B, in the immune system. PMID: 24898386
- Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 accumulation. PMID: 23357576
- Cul4b mutant mouse showed decrease in the number of parvalbumin-positive neurons and altered dendritic properties. PMID: 22763239
- Epiblast-specific deletion of Cul4b prevented embryonic lethality and gave rise to viable Cul4b null mice. PMID: 22453236
- Cul4b is essential for the development of extra-embryonic tissues, but is dispensable for embryogenesis itself. PMID: 22584258
- Cul4b null mouse embryos show severe developmental arrest and usually die before embryonic day 9.5. The placentas in Cul4b heterozygotes were disorganized and were impaired in vascularization, which may contribute to the developmental delay. PMID: 22606329
- study concludes that Cul4B licenses the tristetraprolin (TTP) containing TNF-alpha messenger ribonucleoprotein for loading onto polysomes, and reduction of Cul4B expression shunts the messenger ribonucleoproteins into the degradative pathway PMID: 22262661
- The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported. PMID: 16052071
- Plays a conserved role in the regulation of beta-catenin levels. PMID: 17954973
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亞細胞定位：Nucleus.
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蛋白家族：Cullin family
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